[Disorders in the status of the vessel-thrombocyte and plasma links of the hemostatic system in the pathogenesis of disseminated intravascular coagulation in ischemic heart disease].

Platelet/vascular and plasma elements of hemostasis were investigated in normal subjects and coronary patients under stimulated emotional stress, following the assessment of vascular wall antithrombogenic properties on the basis of evidence from short-term local vascular ischemia (the cuff test). In normal subjects, vascular wall antithrombotic properties remained unchanged, providing a sufficient anticoagulant and thrombolytic support under emotional stress and thereby protecting the body against thrombosis. Coronary patients showed depressed vascular-wall antiaggregant, anticoagulant and fibrinolytic activity and latent disseminated intravascular microcoagulation that tended to progress under mental stress, creating a risk of intravascular thrombosis.

[Effect of inhibitors of radical reactions of lipid oxidation on the electrical activity of snail isolated neurons].

The influence of inhibitors of radical lipid oxidation on completely isolated identified neurons LPa3 was investigated. The correlation was found between the concentration of acting inhibitor and the level of electrical activity alteration of the neuron. The maximum effect was observed at the inhibitor concentration of 10(-15) M.

[Effect of diuretics on the activity of the blood kallikrein-kinin system in experimental inflammation].

Experimental inflammatory edema induced by subplantar administration of dextran was shown to activate the blood kallikrein-kinin system in rats. Furosemide, dichlothiazide and ethacyrnic acid (50 mg/kg) prevented this effect. Ethacrynic acid exerted the most pronounced action.

[Dynamics of cyclase systems and hormonal indices in patients with ischemic heart disease in a state of emotional stress].

A total of 64 male patients with varying forms of coronary heart disease (CHD), aged 43 to 65 years, and free of diabetes mellitus, obesity and arterial hypertension symptoms, were studied in conditions of emotional stress simulated, using the method of mental calculations with shifts of attention under time shortage. Pre- and post-exercise blood levels of cyclic nucleotides (cAMP and cGMP), the somatotropic hormone and immunoreactive insulin were measured. Stress-induced decrease in platelet cAMP/cGMP ratios, indicative of further increase in the functional activity of platelets, was demonstrated in coronary patients with marked coronary atherosclerosis, as contrasted to normal subjects and patients with milder disease.

[Interaction of adrenocorticotropic hormone, cortisol and insulin during emotional tension among ischemic heart disease patients].

Blood levels of the adenocorticotrophic hormone (ACTH), cortisol and insulin were measured in normal subjects and patients with different forms of coronary heart disease (CHD), aged 35 to 60 years and showing no signs of diabetes mellitus, obesity and arterial hypertension, under simulated emotional stress. The majority of the patients, particularly those with unfavorable course of the CHD, showed stress-induced disturbances of hormonal control due to depressed insulin levels in the presence of an insignificant ACTH increment and high cortisolemia. Hormonal rations were shown to be of predictive value in stress-exposed normal subjects and coronary patients alike.

[Hormonal regulation of the hemostasis system in patients with ischemic heart disease during emotional stress].

A total of 75 patients were examined, suffering from various forms of coronary heart disease (CHD) in conditions of emotional stress (ES). It was found that, as the blood anticoagulant activity and fibrinolysis are intensified in CHD patients in response to ES, the catecholamone effect on the blood coagulation inhibitors is decreased, the correlation between these parameters remaining high. In some patients decrease of the blood anticoagulant activity and fibrinolysis depression are observed in response to ES; decreased blood catecholamine concentrations were detected in the presence of high hydrocortisonemia, weakened hormonal effects, and emergence of negative correlation between these effects and the hemostatic system anticoagulant parameters, that evidences exhausted capacity of the anticoagulant system to defense activation.

[Nerve cells of Helix pomatia during hypercapnia].

Hypercapnia leading initially to activation of synaptic activity and of pace-maker mechanism is accompanied later by inactivation of the electro-excitable membrane and is completed by loss of chemosensitivity. Restoration of the properties of the neurone following transition to normal atmospheric air develops in reverse order. All hypercapnic changes of the properties of the electroexcitable and chemosensitive membrane take place at a constant level of the membrane potential which points to stability of K-Na-pump.

[Effect of emotional tension on intravascular coagulation in patients with angiographically established ischemic heart disease].

The effect of simulated emotional stress (ES) on the platelet/vascular and plasma components of the hemostatic system was examined in normal subjects and coronary patients. In coronary patients, prestress hemostatic platelet/vascular and plasma factors were disturbed, their blood showing a tendency to activated intravascular coagulation. Stress further increased the blood thrombogenic potential of coronary patients, causing intravascular coagulation as evidenced by declining cAMP/cHMP ratio, enhanced release of soluble fibrin and fibrinogen-fibrin degradation products (FDPs), and reduced antithrombin III.

[Presynaptic mechanisms of synchronizing fluctuations in the amplitude of synaptic potentials in the central nervous system of Helix lucorum taurica L].

The amplitude of EPSP arising in different command neurons (LPa2, LPa3 and PPa3) of the snail Helix lucorum after stimulation of presynaptic element LPa7 fluctuated synchronously. Synchronous application of acetylcholine on two command neurons showed that synchronous EPSP fluctuations were connected not with postsynaptic but with presynaptic mechanisms. The existence of a special modulating neuron is suggested.

[Desensitization of cholinoreceptors of the somatic membrane of command neurons of Helix lucorum taurica L].

Desensitization of receptors by the rhythmic application of acetylcholine (AC) was studied in Helix lucorum command neurons PPa2, PPa3, LPa2, LPa3. Application of AC induced in them monophasic depolarization wave. Repetitive AC stimulation with intervals less than 1-2 min induced a decrement of the response which gradually reached plato.

[Changes in the hemostatic system and the progression of arteriosclerosis in ischemic heart disease patients].

The effect of standardized mental stress on the hemostatic system was studied in 160 patients with coronary heart disease. The diagnosis of coronary atherosclerosis was documented by selective coronary angiographic findings. Emotional tension was modelled using the method of counting with interswitching in conditions of time deficit, irritating light and sound signals, as well as critical remarks about the work performed.

[Effect of emotional stress on the system of hemostasis in patients with coronary arteriosclerosis].

Under conditions of experimentally induced psychic stress, the changes were studied in the activity of the sympatheticoadrenal system and the thrombocytic-vascular and the plasmic links of the hemostatic system. Ninety-seven men aged 35-61 years and suffering from coronary heart disease without hypertension and circulation insufficiency were studied. The diagnosis of coronary atherosclerosis was confirmed by selestive coronary angiography.