Assessment of Iron-Based Spin-Orbit Coupling Effects in Pt-Fe Heterobimetallic Lantern Complexes via Fe Mössbauer Spectroscopy.

A series of heterobimetallic lantern complexes, [PtFe(SOCR)(pyX)] where R = Me, X = H (), X = NH (), X = SMe (); R = Ph, X = H (), X = NH (), X = SMe (), have been prepared and characterized spectroscopically. Compounds , , and are reported herein for the first time. The high-spin iron(II) sites of - have been investigated using Fe Mössbauer spectroscopy.

Ukrainian healthcare providers under siege during the first year of war: challenges and adaptations.

The overlapping COVID-19 crisis and the war starting in 2022 threaten front-line healthcare workers' mental health, well-being and job retention in Ukraine. This paper provides a synopsis of a panel discussion held by the Global Mental Health Humanitarian Coalition in May 2022 and expert consultations with clinicians between December 2022 and February 2023 on these challenges. The crises created new problems and exacerbated many pre-existing difficulties.

Phenol is a pH-activated linker to gold: a single molecule conductance study.

Single molecule conductance measurements typically rely on functional linker groups to anchor the molecule to the conductive electrodes through a donor-acceptor or covalent bond. While many linking moieties, such as thiols, amines, thiothers and phosphines have been used among others, very few involve oxygen binding directly to gold electrodes. Here, we report successful single molecule conductance measurements using hydroxy (OH)-containing phenol linkers and show that the molecule-gold attachment and electron transport are mediated by a direct O-Au bond.

Manipulating Quantum Interference between σ and π Orbitals in Single-Molecule Junctions via Chemical Substitution and Environmental Control.

Understanding and manipulating quantum interference (QI) effects in single molecule junction conductance can enable the design of molecular-scale devices. Here we demonstrate QI between σ and π molecular orbitals in an ∼4 Å molecule, pyrazine, bridging source and drain electrodes. Using single molecule conductance measurements, first-principles analysis, and electronic transport calculations, we show that this phenomenon leads to distinct patterns of electron transport in nanoscale junctions, such as destructive interference through the para position of a six-membered ring.

Treatment System Adaptations during War: Lessons from Ukrainian Addiction Treatment Providers.

The war in Ukraine has posed significant challenges to the healthcare system. This paper draws upon expert consultations, held between December 2022 and February 2023, focused on HIV/AIDS, addiction, and mental health service delivery during the first year of this war, and following the Global Mental Health Humanitarian Coalition panel discussion in May 2022. This commentary presents the experiences of frontline healthcare workers in Ukraine, challenges, and local adaptations to meet the increased mental health needs of healthcare providers.

Hard-Soft Chemistry Design Principles for Predictive Assembly of Single Molecule-Metal Junctions.

The achievement of atomic control over the organic-inorganic interface is key to engineering electronic and spintronic properties of molecular devices. We leverage insights from inorganic chemistry to create hard-soft acid-base (HSAB) theory-derived design principles for incorporation of single molecules onto metal electrodes. A single molecule circuit is assembled via a bond between an organic backbone and an under-coordinated metal atom of the electrode surface, typically Au.

Macroscopic assessment of nanosilver toxicity to soil denitrification kinetics.

A large increase in commercial and home use of silver nanoparticle (AgNP) products and technologies has raised concerns about their impact on environmental health. While several sources cite soils and sediments as the predominant sink for AgNPs in natural environments, few studies contribute to risk assessment of AgNPs in terrestrial environments. In this study, the effect of AgNPs ([Ag]: 1-100 mg/kg, 15-50 nm with 0-90% polyvinylpyrrolidone [PVP] capping agent) on soil denitrification processes was investigated with batch kinetic experiments using well-characterized AgNPs.

Identification of denitrifying rhizobacteria from bentgrass and bermudagrass golf greens.

Aims: As high rates of nitrogen fertilization are used in turfgrass management, there is a great potential for nitrogen loss. Research on identification of denitrifiers in turfgrass has been limited. Therefore, the aim was to identify denitrifier species and genes from turfgrass roots.

Phytoremediation of pyrene in a Cecil soil under field conditions.

We evaluated the effects of annual ryegrass (Lolium multiflorum Lam.) and phosphorus (P) availability on the dissipation of pyrene added at a concentration of approximately 600 mg kg-1 dry soil in the top 7.5 cm of a Cecil loamy sand (fine, kaolinitic, thermic Typic Kanhapludults) in a 10-month experiment under field conditions in Clemson, South Carolina.

Use of the MIDI-FAME technique to characterize groundwater communities.

Fatty acid methyl ester (FAME) profiles were identified directly from groundwater microbial communities concentrated on and extracted with polycarbonate filters. The sensitivity of this direct extraction method was determined using pure cultures of Acinetobacter junii, Pseudomonas putida and Stenotrophomonas maltophilia. A minimum concentration of 107 cells filter-1 was required to identify the predominant fatty acids from each culture.

Tumor stem cell heterogeneity: implications with respect to classification of cancers by chemotherapeutic effect.

Herein we have considered the types of tumor stem cell heterogeneity that might account for (a) fluctuating degrees of response to chemotherapy in similarly treated individuals bearing a particular neoplasm, and (b) classifications of cancers by chemotherapeutic effect. Fluctuating ratios of T/R to T/O stem cells, as predicted by the mutation theory, will account for (a). In different circumstances at least three phenomena might account for (b): growth fraction differences, differences in T/R to T/O stem cell ratios, or differences with respect to pharmacologic sanctuaries.

Establishment of cross-resistance profiles for new agents.

Sublines of murine leukemias (L1210 and P388) and solid tumors selected for resistance to representatives of all of the chemical and functional classes of clinically useful anticancer drugs have been isolated and established in serial in vivo passage and, in some cases, in vitro culture. Extensive resistance, cross-resistance, and collateral-sensitivity patterns have been established with most of the sublines of the drug-resistant murine leukemias under treatment with greater than 100 different established and clinically useful anticancer drugs or new candidate anticancer drugs currently under study. Patients selected for inclusion in phase I-II trials usually have tumors that have failed to respond to treatment with established clinically useful drugs, either from the start of treatment or during continuing treatment after initial useful response.

Stepwise progress in the treatment of disseminated cancers.

Remarkable progress has been made in curing a significant number of disseminated cancers, but at times the pace has seemed discouragingly slow. When I look back at both the successes and failures, and relate them to current concepts, I cannot help but wonder if the rate of future progress might be accelerated by application of basic tenets of the 40-year-old somatic mutation theory. By this I mean serious consideration of the implications of this theory in interpretation of available data and in the design of future therapeutic regimens.