Publications by authors named "SK Saha"

Objective: Alectinib HCl (ALB-HCl) is a BCS class IV molecule with low solubility and low oral bioavailability. Owing to its low bioavailability, a high dose of ALB-HCl is recommended with food to meet clinical efficacy. Thus, there is a need for a delivery system to overcome the bioavailability concerns.

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  • FGFR inhibitors have shown promise in treating FGFR-altered cholangiocarcinoma, but acquired resistance poses a challenge to their effectiveness.
  • The study utilized diverse investigative methods, including DNA analysis and tissue biopsies, to explore resistance mechanisms in a cohort of patients.
  • Results indicated that a significant number of patients with clinical benefits had specific FGFR2 mutations, but polyclonal resistance was influenced by low drug concentrations and specific mutation types affecting drug efficacy.
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We report a cascade approach for the synthesis of 2,3-dihydropyrroles derivatives via a formal [4 + 1] annulation reaction of α,β-unsaturated imines with generated pyridinium ylides. Importantly, this protocol is compatible with diverse substituted imines as well as pyridinium ylides, constructing 2,3-dihydropyrroles with excellent yield and selectivity. Thereafter, the Merrifield resin-supported pyridinium ylide as a potential C1 synthon was also employed in our strategy and reused several times, resulting in products with excellent yield and diastereoselectivity.

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Background: There is a shortage of rapid, accurate, and low-cost assays for diagnosing enteric fever. The dual-path platform for typhoid (DPPT) assay had high accuracy in retrospective studies with banked plasma samples. We aimed to evaluate the diagnostic accuracy of the DPPT assay in a prospective study using fingerstick capillary blood.

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Background: Significant disparities in Group B Streptococcus (GBS) colonisation and neonatal disease rates have been documented across different geographical regions. For example, Bangladesh reports notably lower rates compared to the United Kingdom (UK) and Malawi. This study investigates whether this epidemiological variability correlates with the immune response to GBS in these regions.

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This report presents near-complete genome sequences of 14 bacteriophages that infect Typhi, identified through environmental surveillance in Bangladesh between August 2021 and June 2022. The bacteriophages, belonging to the genera , , and , exhibit high degrees of sequence similarity and conserved genetic features with previously reported Typhi bacteriophages.

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Orphan drugs are medications that are produced for the treatment of rare diseases. As there is less number of patients, the drug manufacturing companies are not keen in producing these drugs. Due to high costs of research and development and low profitability, companies do not want to invest in manufacturing of orphan drugs.

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It has been shown in recent years that a range of optical diseases have early manifestation in retinal fundus images. It is becoming increasingly important to separate the regions of interest (RoI) upfront in the automated classification pipeline in order to ensure the alignment of the disease diagnosis with clinically relevant visual features. In this work, we introduce Pan-Ret, a semi-supervised framework which starts with locating the abnormalities in the biomedically relevant RoIs of a retinal image in an "annotation-agnostic" fashion.

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  • The study compares the DNA compaction efficiency of two single-head-double-tailed surfactants (DDAB16 and DDAB18) and one triple-head-double-tailed surfactant (MQAS12), finding DDAB18 to be the most efficient and MQAS12 the least.
  • Hybrid materials combining surfactants with silica nanoparticles show improved compaction efficiency due to cooperative binding, allowing for effective DNA compaction at lower surfactant concentrations, which reduces cytotoxicity.
  • The research indicates that the hydrophobicity and structural characteristics of surfactants and nanoparticles significantly influence DNA compaction, supporting the potential design of safe and efficient non-viral vectors for biomedical applications.
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Conjugated diene molecules are highly reactive upon photoexcitation and can relax through multiple reaction channels that depend on the position of the double bonds and the degree of molecular rigidity. Understanding the photoinduced dynamics of these molecules is crucial for establishing general rules governing the relaxation and product formation. Here, we investigate the femtosecond time-resolved photoinduced excited-state structural dynamics of ,-1,3-cyclooctadiene, a large-flexible cyclic conjugated diene molecule, upon excitation with 200 nm using mega-electron-volt ultrafast electron diffraction and trajectory surface hopping dynamics simulations.

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Hexavalent chromium (Cr (VI)), a toxicant of environmental concern, frequently enters into water bodies and produces oxidative stress in fish. The antioxidant enzymes, Superoxide dismutase (SOD), Catalase (CAT), and Glutathion S-transferase (GST) are activated to counteract the oxidative stress in fish. This study explores the pattern of activation of these enzymes in gill, muscle, liver, and kidney tissues of Nile tilapia Oreochromis niloticus exposed to 9.

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We study percolation transition of run and tumble particles (RTPs) on a two dimensional square lattice. RTPs in these models run to the nearest neighbour along their internal orientation with unit rate, and to other nearest neighbours with rates . In addition, they tumble to change their internal orientation with rate .

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The exposure of fish to heavy metals is a significant concern for human health and natural ecosystems. Despite being a critical issue, the extent of contamination in tropical fish from developing countries like Bangladesh remains somewhat unexplored. In this study, ten economically vital fish species (Osteogeneiosus militaris, Arius gagora, Harpadon nehereus, Mugil ephalus, Pseudapocryptes elongates, Apocryptes bato, Labeo bata, Tenualosa toil, Notopterus notopterus, and Pampus chinensis) from the Pasur River, Bangladesh, were analyzed by atomic absorption spectrometer for the concentrations of four concerned heavy metals, viz.

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Hybrid nanoparticles formed by Silica (SiO) coated with cationic gemini surfactants with variable hydroxyl group substituted spacers, 12-4(OH)-12,2Br and 12-4(OH)-12,2Br have shown a great extent of compaction of calf thymus DNA (ct-DNA) compared to conventional counterpart cationic surfactant, dodecyl trimethylammonium bromide (DTAB). Study shows not only the hydrophobicity of the spacer but also the hydrogen bonding interactions between the hydroxyl group substituted spacer and DNA have a great role in DNA compaction. 12-4(OH)-12,2Br is more efficient in compacting ct-DNA compared to 12-4(OH)-12,2Br due to the stronger binding of the former with ct-DNA than the latter.

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Background: To align with the 2030 vision of the World Health Organization (WHO) to ensure 90% of girls receive the HPV vaccine before turning 15, Bangladesh has recently started the (HPV) vaccine campaign nationwide. Therefore, our study aimed to assess the level of its acceptance among parents of eligible daughters in Bangladesh.

Methods: This nationwide cross-sectional study was conducted among the self-identified parents of daughters in the age group of 9-15 years between June 28 and August 2, 2023.

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  • Rising antimicrobial resistance (AMR) in Salmonella Typhi poses a significant threat to typhoid treatment, especially in high-burden countries like Bangladesh, where long-term data is lacking.
  • The study analyzed typhoid cases in Dhaka from 1999 to 2022, finding a decrease in multidrug resistance (MDR) from 38% to 17% and a drop in cotrimoxazole consumption, while resistance to ciprofloxacin remained high (>90%).
  • With a noted decline in MDR, the research suggests that first-line antibiotics may be safely reintroduced for treating typhoid fever, pending further decreases in resistance rates.
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Risk stratification is an important initial step for primary prevention of atherosclerotic cardiovascular diseases. There are a number of scoring systems for this purpose worldwide. We tried to evaluate two most updated scoring systems.

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  • The Letter reports the most accurate measurement so far of the matter-antimatter imbalance during Pb-Pb collisions at a high energy level of 5.02 TeV.
  • It utilizes the Statistical Hadronization framework to determine precise values for the electric charge and baryon chemical potentials, μ_{Q} and μ_{B}.
  • The analysis of antiparticle-to-particle yield ratios shows that the collisions create a system that is generally baryon-free and electrically neutral at midrapidity.
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Nanostructuring can greatly improve the electrode stability of rechargeable battery systems, such as Zn-Ag. In this report, we investigate the physical mechanisms by which nanostructuring alters structural properties of nanomaterials and thereby influences the structural stability of electrodes. We specifically consider the effects of Au-based nanoscaffolds on Ag.

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The majority of the eukaryotic cell surface is decorated with a layer of membrane-attached polysaccharides and glycoproteins collectively referred to as the glycocalyx. While the formation of a bulky glycocalyx has been associated with the cancer progression, the mechanisms by which the glycocalyx regulates cancer invasiveness are incompletely understood. We address this question by first documenting subtype-specific expression of the major glycocalyx glycoprotein Mucin-1 (MUC1) in breast cancer patient samples and breast cancer cell lines.

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With increasing demand for improved protein-rich food, diverse poultry birds like turkey are gaining popularity in India. However, with the rising concerns of antibiotic residues and drug resistance, safe alternatives like formic acid (FA) and thymol (TH) have attracted the attention of researchers as effective replacer of antibiotic growth promoters (AGP). This experiment investigated the effects of combinations of FA and TH on growth performance, immunity, gut microflora and jejunal microstructures in turkey.

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  • The study investigates the prevalence of rectovaginal group B Streptococcus (GBS) colonization in pregnant women during labor and its transmission to newborns in selected low-income and middle-income African and South Asian countries.
  • Conducted across 11 maternity and obstetric facilities, the research involved collecting samples from 6,514 HIV-negative pregnant women at least 37 weeks gestation to analyze GBS culture and serotyping.
  • The findings revealed a 24.1% rate of maternal GBS colonization, with the highest prevalence in Mali (41.1%) and the lowest in Ethiopia (11.6%), highlighting significant regional variations in GBS rates among pregnant women.
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Synthesis of diversely functionalized quinoline-2-carboxylates is illustrated through electrochemical cross-dehydrogenative coupling between -aryl glycinates and methylenecyclopropanes. An extensive range of distinct functionalities is well-compatible under these transition-metal- and oxidant-free mild electrochemical conditions, contributing to a broad substrate scope and practical applicability. Cyclic voltammetric measurements and control experiments suggested a formal [4 + 2] cycloaddition involving radical intermediates, followed by a cyclopropyl ring opening through nucleophilic polar addition, consecutively fabricating C-C and C-N bonds.

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  • - The molecule methyl(10-phenylphenanthren-9-yl)sulfane (MPPS) has been synthesized and studied as a new fluorescent probe, revealing important photophysical properties through a combination of experimental methods and theoretical calculations.
  • - The study highlights how the molecule’s structure, particularly the rotation of its phenyl and phenanthrene rings, affects its fluorescence emissions and lifetimes, with variations observed in different solvent polarities.
  • - MPPS has been successfully utilized to determine critical micelle concentrations (cmc) of various surfactants and further characterized the binding interaction between a gemini surfactant and bovine serum albumin (BSA), confirming its effectiveness in studying microheterogeneous systems.
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Epithelial-to-mesenchymal transition (EMT) is a key process where cells lose their adhesion properties and augment their invasive properties. α-Actinin4 (ACTN4) is an actin crosslinking protein that responds to mechanical stimuli and is found to be elevated in breast cancer patients. While ACTN4 has been implicated in regulating cancer invasiveness by modulating cytoskeletal organization, its nuclear functions remain much less explored.

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