Action of 5,5-diethyl-1,3-oxazine-2,4-dione (dioxone) on respiration and circulation.

The action of 5,5-diethyl-1,3-oxazine-2,4-dione (dioxone) has been studied in rats, rabbits, cats and dogs. Dioxone produced a marked stimulation of respiration in anaesthetized, decerebrate and spinal animals when given in doses that did not induce convulsions. This effect was generally accompanied by a rise in blood pressure, which was more marked in cats than in dogs and rabbits.

Pharmacological properties of 3-phenyl-5beta diethylaminoethyl-1,2,4-oxadiazole.

The general pharmacological properties of Oxolamine (3-phenyl-5beta-diethylaminoethyl-1,2,4-oxadiazole) are described. The antitussive activity of this drug is more apparent in tests involving a diffuse stimulation of the bronchial tree than with electrical stimulation of the superior laryngeal nerve. These results suggest a predominantly peripheral mechanism of action.