Clinical Outcomes after Conservative Management of Cervical Intraepithelial Neoplasia Grade 2 (CIN2) in Women Ages 21-39 Years.

Cervical intraepithelial neoplasia grade 2 (CIN2) frequently regresses, is typically slow-growing, and rarely progresses to cancer. Some women forgo immediate treatment, opting for conservative management (heightened surveillance with cytology and colposcopy), to minimize overtreatment and increased risk of obstetric complications; however, there are limited data examining clinical outcomes in these women. We performed a retrospective cohort analysis of younger women diagnosed with initially untreated CIN1/2, CIN2 and CIN2/3 lesions at Kaiser Permanente Northern California between 2003 and 2015.

A Combinatorial Proteomic Biomarker Assay to Detect Ovarian Cancer in Women.

Ovarian cancer is often fatal and incidence in the general population is low, underscoring the necessity (and the challenges) for advancements in screening and early detection. The goal of this study was to design a serum-based biomarker panel and corresponding multivariate algorithm that can be used to accurately detect ovarian cancer. A combinatorial protein biomarker assay (CPBA) that uses CA125, HE4, and 3 tumor-associated autoantibodies resulted in an area under the curve of 0.

Prenatal organophosphate insecticide exposure and infant sensory function.

Background: Occupational studies suggest that exposure to organophosphate insecticides (OPs) can lead to vision or hearing loss. Yet the effects of early-life exposure on visual and auditory function are unknown. Here we examined associations between prenatal OP exposure and grating visual acuity (VA) and auditory brainstem response (ABR) during infancy.

A Large Family of Centrosymmetric and Chiral f-Element-Bearing Iodate Selenates Exhibiting Coordination Number and Dimensional Reductions.

The exploration of phase formation in the f-element-bearing iodate selenate system has resulted in 14 novel rare-earth-containing iodate selenates, Ln(IO)(SeO) (Ln = La, Ce, Pr, Nd; LnISeO-1), Ln(IO)(SeO)(HO) (Ln = Sm, Eu; LnISeO-2), and Ln(IO)(SeO)(HO)·HO (Ln = Gd, Dy, Ho, Er, Tm, Yb, Lu, Y; LnISeO-3), as well as two new thorium iodate selenates, Th(OH)(IO)(SeO)(HO) (ThISeO-1) and Th(IO)(SeO) (ThISeO-2). LnISeO-3 and ThISeO-2 crystallize in the chiral space group P222, while LnISeO-1, LnISeO-2, and ThISeO-1 crystallize in the centrosymmetric space group P2/c. The numbers of both coordinating and hydrating water molecules crystallized in LnISeO-1, LnISeO-2, and LnISeO-3 increase along these three series, in line with the increasingly negative values of hydration enthalpies of heavier trivalent lanthanide ions.

Durable lesion formation while avoiding esophageal injury during ablation of atrial fibrillation: Lessons learned from late gadolinium MR imaging.

Introduction: Adequate catheter/atrial tissue contact is critical for lesion formation during radiofrequency (RF) ablation of atrial fibrillation (AF). Late gadolinium enhancement magnetic resonance imaging (LGE-MRI) is a unique tool for the evaluation of lesion formation and detection of acute esophageal injury.

Methods: LGE-MRIs were obtained prior, within 24 hours of, and at 115 ± 62 days after first AF ablation in 36 patients.

An Ultrastable Heterobimetallic Uranium(IV)/Vanadium(III) Solid Compound Protected by a Redox-Active Phosphite Ligand: Crystal Structure, Oxidative Dissolution, and First-Principles Simulation.

The first heterobimetallic uranium(IV)/vanadium(III) phosphite compound, NaUV(HPO) (denoted as UVP), was synthesized via an in situ redox-active hydrothermal reaction. It exhibits superior hydrolytic and antioxidant stability compared to the majority of structures containing low-valent uranium or vanadium, further elucidated by first-principles simulations, and therefore shows potential applications in nuclear waste management.

Highly Sensitive Detection of UV Radiation Using a Uranium Coordination Polymer.

The accurate detection of UV radiation is required in a wide range of chemical industries and environmental or biological related applications. Conventional methods taking advantage of semiconductor photodetectors suffer from several drawbacks such as sophisticated synthesis and manufacturing procedure, not being able to measure the accumulated UV dosage as well as high defect density in the material. Searching for new strategies or materials serving as precise UV dosage sensor with extremely low detection limit is still highly desirable.

Phase transition triggered aggregation-induced emission in a photoluminescent uranyl-organic framework.

When exposed to water, the two-dimensional uranyl-organic layered compound [(CH)NH][(UO)(BCPBA)]·2DMF·HO (HBCPBA = 3,5-bis (4'-carboxylphenoxy) benzoic acid) gradually undergoes a complete single-crystal-to-single-crystal phase transition to [(CH)NH][(UO)(BCPBA)]·3.4HO, resulting in an enhanced ligand-ligand interaction between the adjacent layers. This process gives rise to initial quenching of the uranyl photoluminescence followed by subsequent recovery of the photoluminescence with a much elevated intensity, as a unique case of aggregation-induced emission in an extended solid system, further confirmed by DFT analysis on bonding.

Tunable 4f/5f Bimodal Emission in Europium-Incorporated Uranyl Coordination Polymers.

There have been numerous studies on emission-color regulation by the adjustment of molar amounts of multiple trivalent lanthanide cations, such as Eu, Tb, Dy, and others, in many types of solid host materials. Although uranyl emission originating from charge-transfer transitions has been well-recognized and investigated for many decades, as of now there is no report on tunable 4f/5f bimodal emission based on heterobimetallic lanthanide(III) and uranyl(VI) compounds. In most cases, complete energy transfer between uranyl(VI) and lanthanide(III) centers was observed.

Neither Cholinergic Nor Dopaminergic Enhancement Improve Spatial Working Memory Precision in Humans.

Acetylcholine and dopamine are neurotransmitters that play multiple important roles in perception and cognition. Pharmacological cholinergic enhancement reduces excitatory receptive field size of neurons in marmoset primary visual cortex and sharpens the spatial tuning of visual perception and visual cortical fMRI responses in humans. Moreover, previous studies show that manipulation of cholinergic or dopaminergic signaling alters the spatial tuning of macaque prefrontal cortical neurons during the delay period of a spatial working memory (SWM) task and can improve SWM performance in macaque monkeys and human subjects.

Pulmonary Vein Isolation with the Multipolar nMARQ™ Ablation Catheter: Efficacy And Safety In Acute And Long-Term Follow Up.

Pulmonary vein isolation (PVI) is an established therapy for atrial fibrillation (AF). One challenge in the catheter-based treatment of this arrhythmia is to develop an effective and safe ablation approach to achieve durable and consistent lesions around the PVs. The multipolar irrigated radiofrequency (RF) ablation catheter nMARQ was designed as a single-shot device with the aim to achieve these goals.

Outpatient Management of Emergency Department Patients With Acute Pulmonary Embolism: Variation, Patient Characteristics, and Outcomes.

Study Objective: Outpatient management of emergency department (ED) patients with acute pulmonary embolism is uncommon. We seek to evaluate the facility-level variation of outpatient pulmonary embolism management and to describe patient characteristics and outcomes associated with home discharge.

Methods: The Management of Acute Pulmonary Embolism (MAPLE) study is a retrospective cohort study of patients with acute pulmonary embolism undertaken in 21 community EDs from January 2013 to April 2015.

Perceptual learning induces changes in early and late visual evoked potentials.

Studies of visual cortical responses following visual perceptual learning (VPL) have produced diverse results, revealing neural changes in early and/or higher-level visual cortex as well as changes in regions responsible for higher cognitive processes such as attentional control. In this study, we investigated substrates of VPL in the human brain by recording visual evoked potentials with high-density electroencephalography (hdEEG) before (Session 1) and after (Session 2) training on a texture discrimination task (TDT), with two full nights of sleep between sessions. We studied the following event-related potential (ERP) components: C1 (early sensory processing), P1 and N1 (later sensory processing, modulated by top-down spatial attention), and P3 (cognitive processing).

A hydrolytically stable uranyl organic framework for highly sensitive and selective detection of Fe in aqueous media.

We present a depleted uranium-based metal organic framework, UO(CHON)·DMF, that exhibits highly sensitive and selective detection towards Fe ions in aqueous media with an extremely low detection limit of 6.3 ppb. This work offers insight into exploring the potential applications of actinide-based metal organic frameworks in the area of chemical sensing with intrinsic advantages of high selectivity and sensitivity.

Uptake of HPV testing and extended cervical cancer screening intervals following cytology alone and Pap/HPV cotesting in women aged 30-65 years.

Objective: To evaluate the adoption of HPV testing and recommended extended cervical cancer screening intervals in clinical practice, we described yearly uptake of Pap/HPV cotesting and estimated length of time between normal screens by patient characteristics.

Methods: We examined 55,575 Pap/HPV records from 27,035 women aged 30-65 years from the Johns Hopkins Hospital Pathology Data System between 2006 and 2013. Cotest uptake and median times to next screening test for cotests and cytology only were calculated.

Comparison of Medical Therapy Alone to Medical Therapy with Surgical Treatment of Peritonsillar Abscess.

Objective This study was performed to determine whether the efficacy and safety of medical management of uncomplicated peritonsillar abscess (PTA) presenting in the emergency department is equivalent to medical plus surgical therapy. Study Design Case series with chart review. Setting Southern California Permanente Medical Group (SCPMG).

Metal-organic frameworks for radionuclide sequestration from aqueous solution: a brief overview and outlook.

In this Frontier article, we pursue the sequestration of radionuclides from aqueous solution by using recently emerging metal-organic framework (MOF) materials. The design of MOF materials and their corresponding sorption properties towards radionuclides (Cs, Sr, U, Se, and Tc) as well as their interaction mechanisms are highlighted. The present challenges and future prospects of removing radionulides with MOFs as sorbents are also demonstrated.

Protocol for the EMPHASIS study; epigenetic mechanisms linking maternal pre-conceptional nutrition and children's health in India and Sub-Saharan Africa.

Background: Animal studies have shown that nutritional exposures during pregnancy can modify epigenetic marks regulating fetal development and susceptibility to later disease, providing a plausible mechanism to explain the developmental origins of health and disease. Human observational studies have shown that maternal peri-conceptional diet predicts DNA methylation in offspring. However, a causal pathway from maternal diet, through changes in DNA methylation, to later health outcomes has yet to be established.

Breast density does not impact the ability of Videssa® Breast to detect breast cancer in women under age 50.

Breast density is associated with reduced imaging resolution in the detection of breast cancer. A biochemical approach that is not affected by density would provide an important tool to healthcare professionals who are managing women with dense breasts and suspicious imaging findings. Videssa® Breast is a combinatorial proteomic biomarker assay (CPBA), comprised of Serum Protein Biomarkers (SPB) and Tumor Associated Autoantibodies (TAAb) integrated with patient-specific clinical data to produce a diagnostic score that reliably detects breast cancer (BC) as an adjunctive tool to imaging.

Estimation of a significance threshold for epigenome-wide association studies.

Epigenome-wide association studies (EWAS) are designed to characterise population-level epigenetic differences across the genome and link them to disease. Most commonly, they assess DNA-methylation status at cytosine-guanine dinucleotide (CpG) sites, using platforms such as the Illumina 450k array that profile a subset of CpGs genome wide. An important challenge in the context of EWAS is determining a significance threshold for declaring a CpG site as differentially methylated, taking multiple testing into account.

Identifying the Recognition Site for Selective Trapping of TcO in a Hydrolytically Stable and Radiation Resistant Cationic Metal-Organic Framework.

Effective and selective removal of TcO from aqueous solution is highly desirable for both waste partitioning and contamination remediation purposes in the modern nuclear fuel cycle, but is of significant challenge. We report here a hydrolytically stable and radiation-resistant cationic metal-organic framework (MOF), SCU-101, exhibiting extremely fast removal kinetics, exceptional distribution coefficient, and high sorption capacity toward TcO. More importantly, this material can selectively remove TcO in the presence of large excesses of NO and SO, as even 6000 times of SO in excess does not significantly affect the sorption of TcO.

ASCCP Colposcopy Standards: How Do We Perform Colposcopy? Implications for Establishing Standards.

Objectives: The American Society for Colposcopy and Cervical Pathology (ASCCP) Colposcopy Standards recommendations address the role of and approach to colposcopy and biopsy for cervical cancer prevention in the United States. The recommendations were developed by an expert working group appointed by ASCCP's Board of Directors. Working group 3 defined colposcopy procedure guidelines for minimum and comprehensive colposcopy practice and evaluated the use of colposcopy adjuncts.