[Characteristics of erythrocyte membrane permeability for potassium ions in rats with familial spontaneous hypertension].

The kinetics of 42K influx into the erythrocytes was studied in spontaneously hypertensive rats (SHR) during the prehypertensive and early hypertensive stages (aged 10 weeks), as well as in Wistar and Sprague-Dawley rats of the same age. The SHR displayed a significantly slower enhancement of the activity in the erythrocytes than in the Wistar and Sprageu-Dawley rats, which indecates a higher level of passive permeability of the erythrocytic membrane for potassium ions and an enhanced turnover of this ion in the erythrocytes of SHR. The revealed changes are interpreted as a fragment of a larger defect in the membrane of SHR that determines the development of spontaneous hypertension.

[Disorder of erythrocyte membrane permeability in spontaneous genetic hypertension in rats].

The efflux of 22Na from erythrocytes of spontaneously hypertensive rats (SHR) and the ones of Wistar and Spra glue-Dawley aged 8 weeks was studied. The efflux rate of the isotope from erythrocytes with ouabaine blocked active transfer of ions was much higher in the SHR in the prehypertensive and early hypertensive stages than in Wistar and Sprague-Dawley rats. These data suggest that, by comparisons with the Wistar and Sprague-Dawley the SHR have an elevated passive permeability of the erythrocytes membrane to sodium.

[Fluorescence analysis study of the structural lability of biomembranes and their components. II. Higher fatty acids].

Binding constants, quantum yield and temperature relationship of the fluorescence of ionic (1-anilinonaphtalene-8-sulphonate-ANS) and neutral (N-phenyl-1-naphtalamine-PNA) probes have been studied on micellae and ufasomes of natural fat acids. The following regularities have been obtained: 1. The Anion dye (ANS) sharply decreases the intensity of fluorescence on fat acid structures while alkilating the medium, it is not practically bound with them at pH-7; 2.

[Fluorescence analysis study of the structural lability of biomembranes and their components. I. Bovine serum albumin].

The binding constants, quentum yield and temperature dependence of the fluorescence of ionic (1-anilinonaphtalin-8-sulphinate) and neutral (N-phenyl-1-naphtylamine) probes were studied on the molecules of bovine serum albumine with the change of pH and solution ionic strength. On the basis of the data obtained the nature of sorbing forces and structural properties of the albumine molecule concerned are discussed.