ALB inhibits tumor cell proliferation and invasion by regulating immune microenvironment and endoplasmic reticulum stress in clear cell renal cell carcinoma.

Objective: The aim of this work is to identify putative hub genes for the advancement of clear cell renal cell carcinoma (ccRCC) and determine the fundamental mechanisms.

Methods: We employed multiple bioinformatics techniques to screen hub genes. Key hub gene expression levels in ccRCC were assessed.

The natural product micheliolide promotes the nuclear translocation of GAPDH via binding to Cys247 and induces glioblastoma cell death in combination with temozolomide.

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is significantly upregulated in glioblastoma (GBM) and plays a crucial role in cell apoptosis and drug resistance. Micheliolide (MCL) is a natural product with a variety of antitumour activities, and the fumarate salt form of dimethylamino MCL (DMAMCL; commercial name ACT001) has been tested in clinical trials for recurrent GBM; this compound suppresses the proliferation of GBM cells by rewiring aerobic glycolysis. Herein, we demonstrated that MCL directly targets GAPDH through covalent binding to the cysteine 247 (Cys247) residue.

Cyanamide-Based Cyclization Reactions for Nitrogen-Containing Heterocycles Synthesis.

Nitrogen-containing heterocycles, such as indoles and quinolines, serve as the key scaffolds in numerous pharmaceuticals, pesticides, and natural products. The synthesis methods of nitrogen-containing heterocycles show significant scientific and industrial value. As a chemical intermediate featuring dual functional groups, cyanamide plays a crucial role in organic synthesis, directly affecting the development of new drugs and the design of new materials.

Global research landscape and emerging trends of non-coding RNAs in prostate cancer: a bibliometric analysis.

Background: Prostate cancer (PC) is the most frequently diagnosed cancer in men and continues to be a major cause of cancer-related mortality worldwide. In recent years, non-coding RNAs (ncRNAs) have emerged as a significant focus in molecular biology research, playing a pivotal role in the development and progression of PC. This study employed bibliometric analysis to explore the global outputs, research hotspots, and future trends in ncRNA-related PC research over the past 20 years.

Pathway Elucidation and Key Enzymatic Processes in the Biodegradation of Difenoconazole by A-3.

The extensive agricultural use of the fungicide difenoconazole (DIF) and its associated toxicity increasingly damage ecosystems and human health. Thus, an urgent need is to develop environmentally friendly technological approaches capable of effectively removing DIF residues. In this study, strain A-3 was isolated for the first time which can degrade DIF efficiently.

YOLOSeg with applications to wafer die particle defect segmentation.

This study develops the you only look once segmentation (YOLOSeg), an end-to-end instance segmentation model, with applications to segment small particle defects embedded on a wafer die. YOLOSeg uses YOLOv5s as the basis and extends a UNet-like structure to form the segmentation head. YOLOSeg can predict not only bounding boxes of particle defects but also the corresponding bounding polygons.

Enantioselective construction of silicon-stereogenic vinylsilanes from simple alkenes.

The diverse utility of acyclic vinylsilanes has driven the interest in the synthesis of enantioenriched vinylsilanes bearing a Si-stereogenic center. However, the predominant approaches for catalytic asymmetric generation of Si-stereogenic vinylsilanes have mainly relied on transition metal-catalyzed reactions of alkynes with different silicon sources. Here we successfully realize the enantioselective synthesis of linear silicon-stereogenic vinylsilanes with good yields and enantiomeric ratios from simple alkenes under rhodium catalysis.

Taiwanese fathers' experiences following the death of a child to cancer.

This study descried the experiences of fathers who had lost a child to cancer. The participants were eight fathers whose children died following cancer treatment. Semi-structured interviews were conducted, and content analysis identified six major themes: (1) accompanying their child on the final journey home, (2) stabilizing family life, (3) coping with unbearable grief, 4) maintaining the memory and continuing the bond, (5) reflecting on the regrets and contradictions of the treatment process, (6) finding new meaning, and cherishing the present.

Effects of Metabolic Factors on Left Ventricular Diastolic Function in Patients with Obstructive Sleep Apnea.

Purpose: The effect of metabolic factors on cardiovascular risk in obstructive sleep apnea (OSA) is unclear. This study aimed to investigate the effect of metabolic factors on the left ventricular diastolic function in patients with OSA.

Patients And Methods: This cross-sectional study included a total of 478 patients with OSA from September 2018 to September 2023.

Increased Incidence of Surgical Intervention for Otitis Media With Effusion Among Patients With Type 2 Inflammatory Diseases.

Background: Otitis media with effusion (OME) is associated with comorbidities such as allergic rhinitis, gastroesophageal reflux disease, asthma, and more. Many of these comorbidities can be caused by type 2 inflammation (T2I). This study aims to determine the risk of undergoing OME surgery in patients with and without T2I disease.

Effectiveness and safety of negative pressure wound therapy in patients with deep sternal wound infection: a systematic review and meta-analysis.

Background: Deep sternal wound infection (DSWI) is a severe and life-threatening complication following cardiovascular surgery. Negative pressure wound therapy (NPWT) has emerged as a promising therapeutic bridging option for DSWI. In this systematic review and meta-analysis, the authors aimed to evaluate the impact of NPWT on clinical outcomes in patients with DSWI.

Word-of-mouth referrals between patients are a critical component of medical tourism for pediatric hematopoietic cell transplantation.

The increasing popularity of medical tourism has sparked interest from policymakers, researchers, and the media. Factors influencing medical tourism include service quality, availability, economics, and cultural differences. This study aims to analyze the key factors that influence destination selection for medical tourists.

The heart rate on admission was associated with the mortality in elderly patients with hip fractures: a retrospective cohort study from a trauma centre in northwestern China.

Objectives: To evaluate the association between heart rate on admission and mortality in elderly patients with hip fractures.

Design: A retrospective cohort study.

Setting: At a trauma centre in northwestern China.

TCF12 and LncRNA MALAT1 Cooperatively Harness High Cyclin D1 but Low β-Catenin Gene Expression to Exacerbate Colorectal Cancer Prognosis Independently of Metastasis.

Metastasis is a well-known factor worsening colorectal cancer (CRC) prognosis, but mortality mechanisms in non-metastatic patients with poor outcomes are less understood. TCF12 is a transcription factor that can be physically associated with the long non-coding RNA MALAT1, creating an alliance with correlated expression levels in CRC patients. This TCF12-MALAT1 alliance is linked to poorer prognosis independently of age and metastasis.

Personalized Dose Selection for Treatment of Patients with Neuropsychiatric Disorders Using tDCS.

: Individualizing transcranial direct current stimulation (tDCS) parameters can improve precision in neuropsychiatric disorders. One important decision for the clinician is the selection of an appropriate montage-conventional or high-definition (HD)-to implement dose-controlled tDCS while maintaining the patient's safety. : The present study simulated tDCS administration using T1-weighted brain images of 50 dementia, 25 depression patients, and 25 healthy individuals for two conventional and HD montages, targeting the regions of interest (ROIs) in the dorsal and ventral pathways that support language processing.

Highly efficient electroplating of (220)-oriented nano-twinned copper in methanesulfonic copper baths.

The formation of a high-density nanotwinned structure in copper deposits is presently acknowledged as a paramount goal for enhancing the material characteristics of copper. However, the conventional manufacturing processes often involve the incorporation of organic additives, resulting in consequential impurity effects and aging concerns. In this work, we introduce a high-rate approach to fabricate (220)-orientation nanotwinned copper foils in a concentrated methanesulfonate copper solution with mere amount of chloride ions as additives.

Interpretation of machine learning-based prediction models and functional metagenomic approach to identify critical genes in HBCD degradation.

Hexabromocyclododecane (HBCD) poses significant environmental risks, and identifying HBCD-degrading microbes and their enzymatic mechanisms is challenging due to the complexity of microbial interactions and metabolic pathways. This study aimed to identify critical genes involved in HBCD biodegradation through two approaches: functional annotation of metagenomes and the interpretation of machine learning-based prediction models. Our functional analysis revealed a rich metabolic potential in Chiang Chun soil (CCS) metagenomes, particularly in carbohydrate metabolism.

Enhancing generalization in a Kawasaki Disease prediction model using data augmentation: Cross-validation of patients from two major hospitals in Taiwan.

Kawasaki Disease (KD) is a rare febrile illness affecting infants and young children, potentially leading to coronary artery complications and, in severe cases, mortality if untreated. However, KD is frequently misdiagnosed as a common fever in clinical settings, and the inherent data imbalance further complicates accurate prediction when using traditional machine learning and statistical methods. This paper introduces two advanced approaches to address these challenges, enhancing prediction accuracy and generalizability.

Identification of neutrophil extracellular traps (NETs)-related molecular clusters in prostate cancer: Implications for predicting biochemical recurrence.

Objective: To identify neutrophil extracellular traps (NETs)-related molecular clusters and establish a novel gene signature for predicting biochemical recurrence in prostate cancer (PCa).

Methods: The transcriptome and clinicaldata of PCa sampleswere obtained from The TCGA and GEO databases. To identify NET-related molecular clusters, consensus clustering analyses were performed.

Radiomics of Periprostatic Fat and Tumor Lesion Based on MRI Predicts the Pathological Upgrading of Prostate Cancer from Biopsy to Radical Prostatectomy.

Rationale And Objectives: To assess the predictive value of MRI-based radiomics of periprostatic fat (PPF) and tumor lesions for predicting Gleason score (GS) upgrading from biopsy to radical prostatectomy (RP) in prostate cancer (PCa).

Methods: A total of 314 patients with pathologically confirmed prostate cancer (PCa) after radical prostatectomy (RP) were included in the study. The patients were randomly assigned to the training cohort (n = 157) and the validating cohort (n = 157) in a 1:1 ratio.

Novel multiple Z-score models for detection of coronary artery dilation: application in Kawasaki disease.

Background: This study aims to develop Z-Score models to normalize measurements of three coronary arteries and enhance the diagnosis of Kawasaki disease (KD) in children from newborns to 10 years old. Developing a reliable Z-Score model is challenging, as some existing models fail the normality test. Overcoming these challenges is crucial for improving KD diagnosis.

Too beautiful to be fake: Attractive faces are less likely to be judged as artificially generated.

Technological advances render the distinction between artificial (e.g., computer-generated faces) and real stimuli increasingly difficult, yet the factors driving our beliefs regarding the nature of ambiguous stimuli remain largely unknown.

[Effect of Dendrobii Officinalis Caulis water extract on hyperviscosity rats based on TLR4/NF-κB/ICAM-1 signaling pathway].

This study aims to reveal the effect and mechanism of Dendrobii Officinalis Caulis water extract on the rat model of hyperviscosity induced by a high-sugar, high-salt, and high-fat diet. Thirty-six male SD rats were randomized into normal, model, Compound Danshen Tablets(0.5 g·kg~(-1)), and low-, medium-, and high-dose(0.

The LILRB family in hematologic malignancies: prognostic associations, mechanistic considerations, and therapeutic implications.

The leukocyte immunoglobulin-like receptor B (LILRB) proteins, characterized by their transmembrane nature and canonical immunoreceptor tyrosine-based inhibitory motifs (ITIM) signaling, play a pivotal role in maintaining immune homeostasis and are implicated in the pathogenesis of various disease states. This comprehensive review will focus on the intricate involvement of the LILRB family in hematologic malignancies. These receptors have emerged as valuable diagnostic and prognostic biomarkers in leukemia, lymphoma, and myeloma.