Publications by authors named "SG Wang"

Base editing is preferable for bacterial gene inactivation without generating double-strand breaks, requiring homology recombination, or highly efficient DNA delivery capability. However, the potential of base editing is limited by the adjoined dependence on the editing window and protospacer adjacent motif. Herein, we report an unconstrained base-editing system to enable the inactivation of any genes of interest in bacteria.

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Background: Cholesterol metabolism is essential for the development and progression of prostate cancer (PCa). Our previous study provided a new insight of cholesterol metabolism in the systematic management of PCa. However, the comprehensive role of cholesterol metabolism in PCa remains unclear.

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Maternal obesity has deleterious effects on the process of establishing oocyte DNA methylation; yet the underlying mechanisms remain unclear. Here, we found that maternal obesity disrupted the genomic methylation of oocytes using a high-fat diet (HFD) induced mouse model, at least a part of which was transmitted to the F2 oocytes and livers via females. We further examined the metabolome of serum and found that the serum concentration of melatonin was reduced.

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Objective: This study explored prognostic differences between radical cystectomy (RC), tri-modality treatment (TURBt combined with radiotherapy and chemotherapy, TMT), electrocautery (EC) and partial cystectomy (PC) for T2N0M0 MIBC.

Materials And Methods: Using SEER data (2004-2015, 2018-2020), we identified T2N0M0 MIBC patients treated with RC, TMT, EC, or PC. Propensity score matching (PSM, 1:1, caliper=0.

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Background: Urolithiasis is a prevalent urological ailment characterized by increasing prevalence and recurrence rates, resulting in substantial social and economic burden. While men exhibit an incidence rate nearly twice that of women, this gender disparity is gradually diminishing. Nevertheless, the mechanisms underlying this condition remain incompletely elucidated.

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Veterinary medicine is an increasingly feminized field, with growing numbers of veterinary students and professionals identifying as women. Increased representation of women in senior veterinary education leadership has not yet been examined across all global regions. To address this question, we compiled a comprehensive list of veterinary academic executives from veterinary educational institutions listed by the World Veterinary Association, the American Veterinary Medical Association, and the World Organisation for Animal Health.

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  • PROTAC (Proteolysis Targeting Chimera) is a developing technology that focuses on degrading specific proteins related to diseases, showing promise in both lab and clinical settings but facing challenges.
  • Recent advances in targeted protein degradation (TPD) have introduced optimized strategies to address the limitations of conventional PROTACs, improving aspects like drug access, tissue selectivity, and control over the degradation process.
  • The review outlines the progress in PROTAC technology, highlights improvements and new concepts, and aims to offer insights for future innovations and applications in drug design.
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  • Telemedicine uses communication technologies for remote healthcare, especially in urology, and has seen growth due to 5G technology and the COVID-19 pandemic.
  • A comprehensive bibliometric analysis was conducted, reviewing 1,357 articles from 97 countries, revealing a steady increase in research publications over the last two decades.
  • The study identifies key research areas such as telemonitoring effectiveness, teleconsultation cost-benefit analysis, and telesurgery exploration, providing insights for future research directions.
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  • Exosomes are linked to the formation of calcium oxalate (CaOx) kidney stones, and this study explores the role of tRNA-derived small RNAs (tsRNAs) in this process.
  • Urine samples from three CaOx stone patients and three healthy individuals were analyzed, revealing four significantly upregulated DEtsRNAs in the patients, particularly tRF-Lys-TTT-5005c.
  • The research suggests that these DEtsRNAs may influence kidney stone formation by affecting key signaling pathways, indicating their potential as diagnostic biomarkers and treatment targets for nephrolithiasis.
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We aimed to investigate the genomic and tumor microenvironmental (TME) profiles in non-muscle invasive bladder cancer (NMIBC) and explore potential predictive markers for Bacillus Calmette-Guérin (BCG) treatment response in high-risk NMIBC patients (according to European Association of Urology (EAU) risk stratification). 40 patients with high-risk NMIBC (cTis-T1N0M0) who underwent en bloc resection followed by BCG instillation were retrospectively enrolled. Surgical samples were subjected to Next Generation Sequencing (NGS) and multiplex immunofluorescence (mIF) assay.

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We disclose herein an unprecedented Pd-catalyzed difluorocarbene transfer reaction, which assembles a series of structurally interesting chiral spiro ketones with generally over 90% ee. Commercially available BrCFCOK serves as the difluorocarbene precursor, which is harnessed as a user-friendly and safe carbonyl source in this transformation. Preliminary mechanistic studies exclude the formation of free CO in the reaction process, and importantly, we also find that BrCFCOK outcompete gaseous CO and several common CO surrogates in this asymmetric process.

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  • Prostate cancer (PCa) is a common male reproductive system tumor, with three main surgical options: open radical prostatectomy (ORP), laparoscopic radical prostatectomy (LRP), and robot-assisted radical prostatectomy (RARP).
  • A study was conducted to compare the effectiveness of RARP to ORP and LRP by evaluating both oncological outcomes (like biochemical recurrence and positive surgical margins) and functional outcomes (such as urinary continence and recovery of erectile function).
  • The analysis revealed that RARP resulted in lower rates of biochemical recurrence and better recovery of erectile function, but there were no significant differences among the three surgical types concerning positive surgical margins and urinary continence.
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  • * The U.S. has dominated the field, producing over half of the leading institutions and publications, while M. Emberton from University College London emerged as the most prominent author.
  • * The journal "EUROPEAN UROLOGY" had the highest impact factor in 2022, with ongoing studies pointing towards brachytherapy and newer techniques like HIFU, cryotherapy, and IRE, but further research is needed for assessing their safety and long-term effectiveness.
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The combination of androgen signaling inhibitors and PARP inhibitors has shown promising results in clinical trials for the treatment of castration-resistant prostate cancer (CRPC). Multi-target inhibitors can inhibit tumors through different pathways, addressing the limitations of traditional single target inhibitors. We designed and synthesized dual inhibitors targeting AR/AR-Vs and PARP1 using a pharmacophore hybridization strategy.

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Objective: To investigate the efficiency and safety of the pulsatile GnRH therapy in the treatment of male congenital hypogonadotropic hypogonadism (CHH).

Methods: We retrospectively analyzed the clinical data on 45 CHH males treated by pulsatile GnRH therapy in our hospital from January 2013 to March 2023. We treated the patients with gonadorelin at 7-15 μg, one pulse/90 min, and followed them up every month in the first 3 months and then every 3 to 6 months after treatment, for an average of 19.

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Background: Alzheimer dementia (AD) constitutes a major societal problem with devastating neuropsychiatric involvement. Pharmaceutical interventions carry a heightened risk of side effects; thus, nonpharmacological interventions such as music-based interventions (MBIs), including music therapy, are recommended.

Recent Findings: The 2023 Neurology release of the Music Based Intervention Toolkit for Brain Disorders of Aging showcased music's emerging role as an intervention to manage symptoms of various brain disorders while defining the building blocks of MBIs to guide research in the exploration of music's therapeutic potential.

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Sulfide biomineralization is a microorganism-induced process for transforming the environmentally hazardous cadmium into useful resource utilization. This study successfully constructed cadmium sulfide nanoparticles-Rhodopseudomonas palustris (Bio-CdS NPs-R. palustris) hybrids.

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Copper clusters feature prominently in both metalloenzymes and synthetic nanoclusters that mediate catalytic redox transformations of gaseous small molecules. Such reactions are critical to biological energy conversion and are expected to be crucial parts of renewable energy economies. However, the precise roles of individual metal atoms within clusters are difficult to elucidate, particularly for cluster systems that are dynamic under operating conditions.

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  • The Anomalous Hall Effect (AHE) is typically seen in ferromagnetic materials, but researchers discovered AHE signals in the non-magnetic compound LaMgBi, which features diverse Dirac fermions in its band structure.
  • LaMgBi exhibits an exceptionally high anomalous Hall conductivity of 42,356 Ω cm and an anomalous Hall angle of 8.8%, marking the largest values recorded in AHE studies thus far.
  • Additionally, the study found that LaMgBi displays significant axial diamagnetism, attributed to limited motion of Dirac fermions at the Fermi level, highlighting its potential for research in AHE and quantum transport among Bi-based materials.
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  • Fuqi Guben Gao (FQGBG) is a botanical drug used to treat nocturia linked to kidney-yang deficiency by combining several traditional medicinal plants, but its safety and pharmacological effects need further study.
  • Recent research on FQGBG demonstrated its effectiveness in reducing urination and improving immune organ damage in rat models of kidney-yang deficiency, while also assessing its safety in a clinical trial with healthy participants.
  • The results indicated significant improvements in symptoms with no major adverse events occurring during dose escalation, although some minor side effects were reported; pharmacokinetic analysis showed varying levels of certain compounds within FQGBG.
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Tetracycline (TC) and Cu(II) coexist commonly in various waters, which may infiltrate into the subterranean environment through runoff and leaching, resulting in substantial ecological risks. However, the underlying mechanisms why Cu(II) affects the transport of TC in porous media remain to be further explored and supported by more evidence, especially the role of complexation. In this study, the transport of TC with coexisting Cu(II) was comprehensively explored with column experiments and density functional theory (DFT) calculation.

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Biological valorization of lignin, the second most abundant biopolymer on Earth, is an indispensable sector to build a circular economy and net-zero future. However, lignin is recalcitrant to bioupcycling, demanding innovative solutions. We report here the biological valorization of lignin-derived aromatic carbon to value-added chemicals without requesting extra organic carbon and freshwater via reprogramming the marine clade bacterium .

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  • The study aimed to analyze serum lipid profiles in patients with localized osteosarcoma around the knee before and after they underwent neoadjuvant chemotherapy.
  • A cohort of 50 patients was evaluated, showing significant increases in several lipid markers, including total cholesterol and triglycerides, after treatment, indicating a change in lipid metabolism due to chemotherapy.
  • While pretreatment lipid levels did not predict histologic response to chemotherapy, increases in certain lipoproteins may suggest potential prognostic significance related to disease-free survival.
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Background: Prostate cancer is one of the most common types of cancer in the US, and it has a high mortality rate. Diabetes mellitus is also a dangerous health condition. While some studies have examined the relationship between diabetes mellitus and the risk of prostate cancer, there is still some debate on the matter.

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