Effect of serotonin on impulse activity of bulbar cardiovascular neurons.

Alteration of impulse activity of afferent and intercalatory neurons of bulbar cardiovascular center upon serotonin microinjection was demonstrated in acute experiments in rabbit. Afferent neurons were more sensitive to serotonin than interneurons.

Fine electrophysiological analysis of impulse activity of various neuron types in nodose ganglion during intraatrial injection of dalargin.

Experiments on narcotized cats showed that intraatrial injection of dalargin in doses crossing and not crossing the blood-brain barrier modifies impulse activity of nodose ganglion neurons.

Effect of thyrotropin-releasing hormone on activity of bulbar cardiovascular neurons.

Acute experiments on narcotized cats showed that intravenous injection of thyrotropin-releasing hormone (20 microg/kg) inhibited discharge activity of most afferent neurons and interneurons in the bulbar cardiovascular center.

Role of the autonomic nervous system in the development of cardiac arrhythmias in cats with acute myocardial ischemia receiving thyroliberin.

The role of the autonomic nervous system in the development of ischemic cardiac arrhythmias was studied in acute experiments on cats receiving thyrotropin-releasing hormone. Bilateral vagotomy attenuated, while bilateral transection of cardiac branches of the stellate ganglia completely abolished the antiarrhythmic effect of thyrotropin-releasing hormone.

Effect of thyrotropin-releasing hormone on the development of cardiac arrhythmias during stimulation of sensorimotor cortex in cats.

Preliminary intravenous injection of thyrotropin-releasing hormone in a dose of 20 g/kg to cats with developing myocardial ischemia during stimulation of the cerebrocortical sensorimotor zone had a pronounced antiarrhythmic effect.

Changes in neuronal pulse activity of bulbar cardiovascular center after administration of dynorphin A1-13.

Acute experiments on cats showed that dynorphin A(1-13) modulates pulse activity of afferent neurons and interneurons in the bulbar cardiovascular center against the background of stable blood pressure.

Effect of TRH on the development of ischemic cardiac arrhythmias in cats.

Acute experiments on cats showed that intravenous injection of thyrotropin-releasing hormone prevented blood pressure drop and produced a pronounced antiarrhythmic effect.

Effect of intravenous injection of DAGO on neuronal activity in bulbar cardiovascular center.

Effects of intravenous injection of DAGO on impulse neuronal activity of the bulbar cardiovascular center were studied in acute experiments on cats narcotized with Nembutal. DAGO-induced changes in activity of sensory neurons and interneurons were unidirectional and preceded hemodynamic shifts. The antiarrhythmic effect of DAGO is due to its direct action on neurons of the bulbar cardiovascular center.

Peculiarities of ischemic cardiac arrhythmias in cats against the background of stimulation of sensorimotor cortex and administration of selective opiate receptor agonists.

In acute experiments on Nembutal-anesthetized cats, the effect of opiate receptor agonists DAGO, DSLET, and dinorphin A(1-13) on the incidence of idioventricular rhythm disturbances, including ventricular tachycardia and fibrillation, was studied under conditions of occlusion of circumflex branch of the left coronary artery and stimulation of the sensorimotor cortex. The most pronounced effects were observed with DSLET and dinorphin A(1-13). These preparations completely prevented ventricular fibrillation.

[Characterization of neurons of the nodose ganglion having constant impulse activity].

In acute experiments on cats hemodynamic distress changed the impulse activity of irregular neurons of ganglion nodosum and not the regular neurons. Irregular neurons get the afferent information to myelinated and non-myelinated fibers of n. vagi.

[The mechanism of the action of dalargin in experimental myocardial ischemia].

In acute experiments on cats it has been shown that dalargin possess antiarrhythmic affect in myocardial ischemia. Antiarrythmic effect of dalagrig may be connected both with reflex and with direct action of dalargin on neurons structure, which

[Mechanism of the antiarrhythmic effect of laser irradiation].

Acute experiments were performed to study the role of afferent impulses from the heart receptors which pass by different vagal fibers during intraatrial laser irradiation. Double laser irradiation of the right atrium seemed more effective than a single one as to decreasing ventricular arrhythmias during cardiac ischemia. It is shown that the antiarrhythmic effect of intraatrial laser irradiation may be due to the change of the afferent information passing by myelinated vagal fibers.