Effect of temperature cycles on the sleep-like state in Hydra vulgaris.

Background: Sleep is a conserved physiological phenomenon across species. It is mainly controlled by two processes: a circadian clock that regulates the timing of sleep and a homeostat that regulates the sleep drive. Even cnidarians, such as Hydra and jellyfish, which lack a brain, display sleep-like states.

Inhibitory effects of Valeriana fauriei root extract on serotonin uptake in vitro caused by the interaction among its active ingredients including a new compound.

Ethnopharmacological Relevance: The root of Valeriana fauriei Briq. (VF) is a folk medicine registered in the Japanese Pharmacopeia 18th Edition. Valeriana plants have been utilized as sedatives and antidepressants in Europe, but only a few pharmacological reports have focused on VF.

Lumbar Spondylolysis After Posterior Corrective Fusion for Adolescent Idiopathic Scoliosis: A Report of Two Cases and Literature Review.

After corrective surgery for adolescent idiopathic scoliosis (AIS), patients can return to sports activities without restrictions. While there have been many reports of long-term disc degeneration between adjacent segments after posterior corrective fusion, the effects of sports activities on adjacent segments after corrective fusion surgery are not well understood. Particularly, cases of acquired spondylolysis after long fusion surgeries for scoliosis are rare.

Association Between Kyphosis and Sleep Disturbance in Community-Dwelling Older Adults: The Locomotive Syndrome and Health Outcome in Aizu Cohort Study.

Purpose: Worsening sagittal alignment of the spine, particularly kyphosis, may cause difficulty in assuming a supine position, restricting sleeping posture and movement and potentially leading to sleep disturbances. However, no studies have explored the relationship between sagittal spinal alignment and sleep disturbance. This study aimed to clarify the relationship between sagittal spinal alignment and sleep disturbance.

[Survey Report on Assistant Work of Radiological Technologist During Angiography and Intervention Radiology Procedure].

Purpose: Investigating the status and challenges associated with radiological technologists acting as assistants during angiography and interventional radiology (IVR) through task shift/share.

Methods: The survey period was from August 1, 2023 to September 30, 2023. A 10-item questionnaire survey was conducted nationwide, targeting 676 hospitals equipped with angiography facilities.

Effect of Meroterpenoids from Sargassum macrocarpum on the Inhibition of Amyloid Polypeptide Aggregation.

Amyloid polypeptide aggregation is considered one of the factors involved in the pathogenesis of Alzheimer's disease (AD) and type 2 diabetes (T2D), and the number of affected patients increases as the population ages. Amyloid β (Aβ) found in the brain of patients with AD and human islet amyloid polypeptide (hIAPP) found in the pancreas of patients with T2D are thought to be cytotoxic during the aggregation process, especially the low-molecular-weight oligomers that are aggregation intermediates. In this study, meroterpenoids isolated and structurally determined from the brown alga Sargassum macrocarpum were evaluated for their ability to inhibit hIAPP aggregation.

Simultaneous Analysis of Imidazole Dipeptides, Constituent Amino Acids, and Taurine in Meats Using the Highly Sensitive Labeling Reagent l-FDVDA and PBr Column.

Imidazole dipeptides (IDPs) are found in the skeletal muscles and brains of various animals, and they exhibit unique functions like antioxidant and antiaging properties. Despite their importance, the metabolic mechanisms and physiological roles of IDPs remain unclear. Herein, we propose a method for the simultaneous analysis of IDPs, their constituent amino acids, and taurine, which are difficult to separate using conventional labeling reagents or columns, using liquid chromatography-single quadrupole mass spectrometry with PBr column and our highly sensitive labeling reagent, 1-fluoro-2,4-dinitrophenyl-5-l-valine-,-dimethylethylenediamineamide (l-FDVDA).

Effect of locomotive syndrome on knee pain in severe knee osteoarthritis.

Background: Locomotive syndrome (LS) presents symptoms related to decreased mobility due to musculoskeletal disorders. Knee osteoarthritis (KOA) is a significant public health concern linked to age-related musculoskeletal issues and is among the conditions contributing to LS. Age-related lower extremity muscle weakness exacerbates knee pain in KOA, but the impact of LS on knee pain is not clear, prompting the present investigation.

The Icelandic Mutation (APP-A673T) Is Protective against Amyloid Pathology In Vivo.

A previous epidemiological study in Northern Europe showed that the A673T mutation (Icelandic mutation) in the amyloid precursor protein gene () can protect against Alzheimer's disease (AD). While the effect of the A673T mutation on APP processing has been investigated primarily in vitro, its in vivo impact has not been evaluated. This is mainly because most existing AD mouse models carry the Swedish mutation.

Risk of colorectal cancer among fecal immunochemical test-positive individuals by timing of previous colonoscopy: A multicenter analysis.

Background And Aim: The risk of colorectal cancer among fecal immunochemistry test-positive individuals who had undergone previous colonoscopies remains unclear. Therefore, this study aimed to determine the differences in the risk of colorectal cancer among fecal immunochemistry test-positive individuals according to the timing of their previous colonoscopies.

Methods: This multicenter, retrospective, observational study was conducted in Japan as a subgroup analysis of the J-SCOUT study (UMIN000040690), which integrated and analyzed a database comprising all colonoscopies performed at participating Japanese institutions between 2010 and 2020.

Postpartum hair loss is associated with anxiety.

Aim: This study examined the relationship between postpartum hair loss and psychological symptoms.

Methods: This questionnaire-based, cross-sectional study included postpartum women who had delivered at two facilities and completed the questionnaire 10-18 months after delivery. Study protocols were sent by mail in two parts.

Nasal obstruction during development leads to defective synapse elimination, hypersynchrony, and impaired cerebellar function.

Nasal respiratory disorders are linked to craniofacial anomalies and systemic dysfunctions. However, the implications of nasal respiratory disorders on brain development and their subsequent impact on brain functionalization remain largely unknown. Here, we describe that nasal obstruction from postnatal developmental stages in mice precipitates deficits in cerebellum-associated behaviors and compromised refinement and maturation of neural circuits in the cerebellum.

Influence of Knee Osteoarthritis Severity, Knee Pain, and Depression on Physical Function: A Cross-Sectional Study.

Purpose: Decreased physical function with increasing life expectancy is a public health concern worldwide. Knee osteoarthritis (KOA) is considered one of the primary illnesses causing decreased physical function. Depression affects decreased physical function and is closely related to knee pain in KOA.

Remote Orthotic Fabrication Method Using Small Three-Dimensional Printers and Computed Tomography Data: A Technical Report.

Introduction: Computer-aided design and manufacturing (CAD/CAM) methods have gained prominence in early orthotic provision.　This study introduces an innovative approach using compact three-dimensional (3D) printers and computed tomography data to generate segmented body models for traditional Damen corset orthoses.　The goals included evaluating the comfort and fit of orthoses and assessing the effectiveness of our approach for prosthetic companies with limited financial resources.

Radiographic Knee Osteoarthritis Is a Risk Factor for the Development of Dementia: Locomotive Syndrome and Health Outcomes in the Aizu Cohort Study.

Objective: Osteoarthritis is linked to dementia, but no longitudinal studies have established this connection. This prospective cohort study from the Locomotive Syndrome and Health Outcome in Aizu Cohort Study (LOHAS) aimed to determine if knee osteoarthritis (KOA) independently predicts dementia in adults aged 65 and above.

Methods: Participants were classified by the Kellgren-Laurence scale into no/minimal KOA (grades 0 and I) and definitive KOA (grade II or higher).

Genome profiling with targeted adaptive sampling long-read sequencing for pediatric leukemia.

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