Maxillofacial trauma in two rural level II trauma centers.

A 10-year retrospective study of maxillofacial trauma cases in Southeast Missouri reveals the causes of the trauma and profiles the age and gender of the victims. In contrast with the findings of urban institutional studies, which are more commonly reported, motor vehicle accidents accounted for the majority of these cases.

The influence of fetal hemoglobin on the clinical expression of sickle cell anemia.

The variable levels of HbF in sickle cell anemia reflect the heterogeneous genetic mix of the beta s-gene-cluster haplotypes and coinheritance of alpha-thalassemia-2 in American SS patients. Clinical severity is less when the level of HbF reaches 20% or 1.2 g/dl or more.

Beta-cluster haplotypes, alpha-gene status, and hematological data from SS, SC, and S-beta-thalassemia patients in southern California.

The beta-gene-cluster haplotype and alpha-gene status were determined for 221 patients with sickle cell anemia, 41 with SC disease, and 21 with S-beta-thalassemia. Among SS patients, eleven beta S haplotypes were found in 21 combinations. Three haplotypes--the Benin (Ben) [---+-], the Central African Republic (CAR) [+---+], and the Senegal (Sen) [+- ]--comprise 61%, 21%, and 10% of the chromosomes, respectively.

Characterization of a high-gain picosecond flash-lamp-pumped Nd:YAG regenerative amplifier.

We evaluate the performance of a novel 10-Hz picosecond Nd:YAG regenerative amplifier configured as a selffiltering unstable resonator. Pulse energies of ~60 mJ in ~100 psec at 1.06 microm are achieved using a single 6-mm-diameter Nd:YAG rod, while mode-matching requirements are minimized.

[Assessment of normal values in 5- to 9-year-old children with the Kurth motometric Rostock-Oseretzky Scale].

197 children, from 5.0 to 9.0, were subjected to testing by the Rostock-Oseretzki scale.

The myeloperoxidase gene is translocated from chromosome 17 to 15 in a patient with acute promyelocytic leukemia.

This study demonstrates that a differentiation-specific gene, the myeloperoxidase (MPO) gene, is translocated in a patient with acute promyelocytic leukemia (APL). The MPO gene recently has been mapped to chromosome #17, close to the breakpoint involved in the t(15;17) commonly seen in APL. By in situ hybridization, we showed that this gene was translocated from chromosome #17 to #15 in an APL patient.

Genetic mechanisms of tumor-specific loss of 11p DNA sequences in Wilms tumor.

Wilms tumor, a common childhood renal tumor, occurs in both a heritable and a nonheritable form. The heritable form may occasionally be attributed to a chromosome deletion at 11p13, and tumors from patients with normal constitutional chromosomes often show deletion or rearrangement of 11p13. It has been suggested that a germinal or somatic mutation may occur on one chromosome 11 and predispose to Wilms tumor and that a subsequent somatic genetic event on the normal homologue at 11p13 may permit tumor development.

[The square search test in connection with acoustic evoked brain stem potentials].

A random sample of 15 patients suffering from multiple sclerosis without acute episodes and at least partially able to work, shows to a high degree of statistical certainty that reduction in amplitude of acoustically evoked brain stem potentials (BAEP) is closely linked with beta-weighted performance value of the square search test (QSP).

Nonrandom loss of maternal chromosome 11 alleles in Wilms tumors.

A series of gene probes for chromosome 11 has been used to study the genetic events associated with the development of Wilms tumor. Examination of DNA samples from five patients with Wilms tumor in whom the tumors showed loss of chromosome 11 alleles and their parents indicate that alleles lost in the tumors are of maternal origin. These data suggest that the parental derivation of chromosome 11 alleles lost in these Wilms tumors is not random.

The localization of the human myeloperoxidase gene is in close proximity to the translocation breakpoint in acute promyelocytic leukemia.

The human myeloperoxidase (MPO) gene has recently been cloned in our laboratory. Southern blot hybridization of our MPO cDNA to DNA from a somatic cell hybrid clone panel revealed that the MPO cosegregated with human chromosome 17. In situ hybridization mapped the MPO gene to chromosome 17q22-24.

Lateral sinus thrombosis: diagnosis and treatment--a case report.

Lateral sinus thrombosis is a difficult diagnostic problem. Specialized computerized tomography allows non-invasive preoperative visualization of sinus contents enabling the surgeon to make a definitive diagnosis with appropriate preoperative planning. This case report details these specialized techniques and their application to a case of lateral sinus thrombosis.

Ectopic gastric mucosa in the cervical esophagus.

Ectopic gastric mucosa is a known entity of the mid and lower esophagus which was initially described by Schmidt in 1805. The presence of ectopic gastric mucosa in the cervical esophagus, however, was not described. A review of the literature reveals that ectopic gastric mucosa of the cervical esophagus is not uncommon, but symptoms rarely have been attributed to its presence.

Single-frequency phase-conjugate laser resonator using stimulated Brillouin scattering.

An experimental investigation of a phase-conjugate laser resonator using a Nd:YAG gain medium and incorporating Brillouin-enhanced four-wave mixing is reported. Phase-conjugate reflectivities of greater than unity and stable oscillation between a single laser frequency and a counterpropagating Stokes frequency are demonstrated.

Localization of the human catalase and apolipoprotein A-I genes to chromosome 11.

Studies of the catalase and apolipoprotein A-I genes are pertinent to the understanding of human disease. Not only are these genes involved in acatalasemia and atherosclerosis, respectively, but they are also important gene markers for chromosome 11, deletions of which are involved in the development of Wilms tumor. We have used in situ hybridization to localize these genes to specific bands on chromosome 11.

The estimation of Hb A2 in the presence of Hb C or Hb E by reverse phase high performance liquid chromatography.

Although Hb-C may be separated from Hb A2 by some ion exchange methods, most will not separate Hb E and Hb A2. The delta chain can be readily separated from the beta C, beta E and beta O-Arab chains by reverse phase HPLC. Hence, reverse phase HPLC provides a means of quantitatively determining Hb A2 in the presence of Hb C, Hb E, and Hb O-Arab.

A study of the minor peaks in high performance liquid chromatograms of globin chains on reversed phase columns.

The high performance liquid chromatograms of the hemoglobins in a hemolysate show minor peaks on reversed phase columns in addition to the expected major peaks of the alpha, beta, and gamma chains. One of these had previously been identified as the delta chain. The material in the most prominent minor peak which is termed "pre-beta" is indistinguishable from the normal beta chain in amino acid composition, but the difference has not been identified.