One-Versus-Others Attention: Scalable Multimodal Integration for Biomedical Data.

Multimodal models have become increasingly important as they surpass single-modality approaches on diverse tasks ranging from question-answering to disease diagnosis. Despite the importance of multimodal learning, existing efforts focus on vision-language applications, where the number of modalities rarely exceeds four (images, text, audio, video). However, data in healthcare domain, may include many more modalities like X-rays, PET scans, MRIs, genetic screening, genomic data, and clinical notes, creating a need for both efficient and accurate data integration.

How Do We Get the Public Into Public Health Research? Learnings and Key Recommendations From Initiating a Community Involvement Project Scheme.

Introduction: There are many recognised benefits of public involvement, including more relevant research. The COVID-19 pandemic highlighted the existing health inequalities and disparities in access to care and treatment for under-served groups, necessitating meaningful and sustainable approaches to engaging them in health research. However, there is limited guidance to suggest what groundwork and processes are necessary for initiating such projects.

[Development of competencies in the Medical Informatics Initiative (MII)-educational offers for a competent and secure handling of medical data].

In order to achieve the goals of the Medical Informatics Initiative (MII), staff with skills in the field of medical informatics and data science are required. Each consortium has established training activities. Further, cross-consortium activities have emerged.

Obstetric-Focused POCUS Training for Medical Students.

Point of care ultrasound (POCUS) is rapidly expanding throughout the United States. Due to its ability to quickly and accurately diagnose and guide therapy for critical conditions, POCUS is becoming routine in many specialties, with established guidelines in fields such as emergency medicine and critical care 1, 2, 3. For example, a study entitled "Ultrasound Integration in Undergraduate Medical Education: Comparison of Ultrasound Proficiency Between Trained and Untrained Medical Students" initiated an Emergency Medicine POCUS curriculum for first-year medical students that showed an increase in ultrasound capability 4.

Conjunctival melanoma: Insights into classification, outcomes, and biomarkers.

Conjunctival melanoma is quite rare, estimated at approximately 0.5 incidence per 1 million persons per year. This malignancy arises from a pre-existing nevus (7%), primary acquired melanosis (74%), or de novo without pre-existing condition (19%) and develops most often in patients with Fitzpatrick skin types I (23%) and II (62%).

The association between specific narrative elements and patient perspectives on acute pain treatment.

Background: Narratives are effective tools for communicating with patients about opioid prescribing for acute pain and improving patient satisfaction with pain management. It remains unclear, however, whether specific narrative elements may be particularly effective at influencing patient perspectives.

Methods: This study was a secondary analysis of data collected for Life STORRIED, a multicenter RCT.

In-utero Diagnosis of Prostatic Embryonal Rhabdomyosarcoma.

Though rhabdomyosarcoma is the most common soft-tissue tumor diagnosed in children there are no reported cases of prenatally detected prostatic embryonal rhabdomyosarcoma. This report demonstrates the first reported case of this phenomenon and its subsequent workup, diagnosis, and treatment.

Evaluation of Open-Source Tools for Differential Privacy.

Differential privacy (DP) defines privacy protection by promising quantified indistinguishability between individuals who consent to share their privacy-sensitive information and those who do not. DP aims to deliver this promise by including well-crafted elements of random noise in the published data, and thus there is an inherent tradeoff between the degree of privacy protection and the ability to utilize the protected data. Currently, several open-source tools have been proposed for DP provision.

Extracellular Vesicle-microRNAs as Diagnostic Biomarkers in Preterm Neonates.

Neonates born prematurely (<37 weeks of gestation) are at a significantly increased risk of developing inflammatory conditions associated with high mortality rates, including necrotizing enterocolitis, bronchopulmonary dysplasia, and hypoxic-ischemic brain damage. Recently, research has focused on characterizing the content of extracellular vesicles (EVs), particularly microRNAs (miRNAs), for diagnostic use. Here, we describe the most recent work on EVs-miRNAs biomarkers discovery for conditions that commonly affect premature neonates.

Performance of AAP Clinical Practice Guideline for Febrile Infants at One Pediatric Hospital.

Background: In the absence of procalcitonin, the American Academy of Pediatrics' clinical practice guideline (CPG) for evaluating and managing febrile infants recommends using previously untested combinations of inflammatory marker thresholds. Thus, CPG performance in detecting invasive bacterial infections (IBIs; bacteremia, bacterial meningitis) is poorly understood.

Objective: To evaluate CPG performance without procalcitonin in detecting IBIs in well-appearing febrile infants 8 to 60 days old.

Retinal cavernous hemangioma in a newborn: an unusual presentation of a rare tumor.

Retinal cavernous hemangioma (RCavH) is an uncommon, benign, vascular tumor of venous aneurysms. It can be sporadic or inherited in an autosomal-dominant pattern as part of an oculoneurocutaneous syndrome. Some affected patients are asymptomatic, and others have symptoms related to retinal dragging and vitreous hemorrhage.

Relationship between Serum Ferritin and Outcomes in β-Thalassemia: A Systematic Literature Review.

Among the difficulties of living with β-thalassemia, patients frequently require blood transfusions and experience iron overload. As serum ferritin (SF) provides an indication of potential iron overload, we conducted a systematic literature review (SLR) to assess whether SF levels are associated with clinical and economic burden and patient-reported outcomes (PROs). The SLR was conducted on 23 April 2020 and followed by analysis of the literature.

[School-based Prevention of the Abusive Dissemination of Sexually Explicit Images on the Internet: Development and Evaluation of the SPuR Program].

Sexting, defined as sending and receiving self-produced, sexually explicit images, is a widespread phenomenon among adolescents, which can have negative consequences, especially if an abusive dissemination occurs. In this study, a program on the prevention of the abusive distribution of sexually explicit images was developed and implemented for grades 6 and 7.The programwas evaluated using a pre-, post- and follow-up design.

Systematic literature review of schizophrenia clinical practice guidelines on acute and maintenance management with antipsychotics.

Clinical practice guidelines (CPGs) translate evidence into recommendations to improve patient care and outcomes. To provide an overview of schizophrenia CPGs, we conducted a systematic literature review of English-language CPGs and synthesized current recommendations for the acute and maintenance management with antipsychotics. Searches for schizophrenia CPGs were conducted in MEDLINE/Embase from 1/1/2004-12/19/2019 and in guideline websites until 06/01/2020.

A Systematic Literature Review of the Relationship between Serum Ferritin and Outcomes in Myelodysplastic Syndromes.

Anemia is the most common form of cytopenia in patients with myelodysplastic syndromes (MDS), who require chronic red blood cell transfusions and may present high serum ferritin (SF) levels as a result of iron overload. To better understand the potential effects of high SF levels, we conducted a systematic literature review (SLR) to identify evidence on the relationship between SF levels and clinical, economic, or humanistic outcomes in adult patients with MDS. Of 267 references identified, 21 were included.

Interaction between Discs large and Pins/LGN/GPSM2: a comparison across species.

The orientation of the mitotic spindle determines the direction of cell division, and therefore contributes to tissue shape and cell fate. Interaction between the multifunctional scaffolding protein Discs large (Dlg) and the canonical spindle orienting factor GPSM2 (called Pins in Drosophila and LGN in vertebrates) has been established in bilaterian models, but its function remains unclear. We used a phylogenetic approach to test whether the interaction is obligate in animals, and in particular whether Pins/LGN/GPSM2 evolved in multicellular organisms as a Dlg-binding protein.

Implementation of a Multifactorial Strategy Including Direct Bedding Is Associated With a Rapid and Sustained Reduction in Left Without Being Seen.

Objective Improve left without being seen (LWBS) in our high volume, tertiary care trauma center. Prior to intervention, our LWBS rate was 4.4%.

[Antihypertensive drugs in psychiatry : Prescription behavior and potential drug-drug interactions].

Background: Patients with mental illnesses are at increased risk of cardiovascular disease-related mortality. Antihypertensive drugs are used particularly for the prophylaxis and treatment of cardiovascular diseases. In combination with psychiatric medication there is a potential for interaction, which can impair the achievement of therapeutic goals.