De novo synthesis of the pyrimidine, cytidine triphosphate (CTP), is crucial for DNA/RNA metabolism and depends on the CTP synthetases, CTPS1 and -2. Partial CTPS1 deficiency in humans has previously been shown to lead to immunodeficiency, with impaired expansion of T and B cells. Here, we examine the effects of conditional and inducible inactivation of Ctps1 and/or Ctps2 on mouse embryonic development and immunity.
View Article and Find Full Text PDFBull Soc Sci Med Grand Duche Luxemb
February 2015
The personality and the achievements of Professor Dr. Félicien M. Steichen, who was born in Luxembourg (10.
View Article and Find Full Text PDFBull Soc Sci Med Grand Duche Luxemb
December 1990
Bull Soc Sci Med Grand Duche Luxemb
December 1990
Bull Soc Sci Med Grand Duche Luxemb
October 1971
Bull Soc Sci Med Grand Duche Luxemb
March 1963
Bull Soc Sci Med Grand Duche Luxemb
October 1961
Bull Soc Sci Med Grand Duche Luxemb
October 1960
Bull Soc Sci Med Grand Duche Luxemb
June 1960