Patients' experiences with methylcobalamin injections in amyotrophic lateral sclerosis.

Background And Objectives: Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease with no definitive treatment. Vitamin B12 is not a Food and Drug Administration-approved treatment in the United States, although it has been prescribed off-label as ultra-high-dose methylcobalamin, which has been shown to be safe and effective in slowing functional decline in patients with ALS. This study evaluates the impact of Vitamin B12 injections on the quality of life of five patients.

The Impact of COVID-19 on Families With Pediatric Muscular Dystrophy Patients.

The coronavirus disease 2019 (COVID-19) pandemic resulted in unprecedented changes in daily activities and healthcare services. In the United States, stay-at-home orders and social distancing measures were put, and school closures impacted many students. The psychological impact of the COVID-19 pandemic has been shown to have wide-ranging and long-term effects.

Applying Lessons Learned from the COVID-19 Pandemic to Future Threats to the Perinatal Care System.

Introduction: Health care systems will continue to face unpredictable challenges related to climate change. The COVID-19 pandemic tested the ability of perinatal care systems to respond to extreme disruption. Many childbearing people in the United States opted out of the mainstream choice of hospital birth during the pandemic, leading to a 19.

HDAC Inhibition Regulates Cardiac Function by Increasing Myofilament Calcium Sensitivity and Decreasing Diastolic Tension.

We recently established a large animal model that recapitulates key clinical features of heart failure with preserved ejection fraction (HFpEF) and tested the effects of the pan-HDAC inhibitor suberoylanilide hydroxamic acid (SAHA). SAHA reversed and prevented the development of cardiopulmonary impairment. This study evaluated the effects of SAHA at the level of cardiomyocyte and contractile protein function to understand how it modulates cardiac function.

Birth during the Covid-19 pandemic: What childbearing people in the United States needed to achieve a positive birth experience.

Background: The COVID pandemic exposed many inadequacies in the maternity care system in the United States. Maternity care protocols put in place during this crisis often did not include input from childbearing people or follow prepandemic guidelines for high-quality care. Departure from standard maternity care practices led to unfavorable and traumatic experiences for childbearing people.

A revised position for the primary strand of the Pleistocene-Holocene San Andreas fault in southern California.

The San Andreas fault has the highest calculated time-dependent probability for large-magnitude earthquakes in southern California. However, where the fault is multistranded east of the Los Angeles metropolitan area, it has been uncertain which strand has the fastest slip rate and, therefore, which has the highest probability of a destructive earthquake. Reconstruction of offset Pleistocene-Holocene landforms dated using the uranium-thorium soil carbonate and beryllium-10 surface exposure techniques indicates slip rates of 24.

Risk Factors for Prolonged Symptoms of Mild Traumatic Brain Injury: A Pediatric Sports Concussion Clinic Cohort.

Objective: To examine predictors of prolonged symptom duration from mild traumatic brain injury (mTBI) in a pediatric sports medicine specialty clinic cohort as these predictors may be distinct in this population.

Design: Retrospective chart review.

Setting: Outpatient specialty clinic.

Evidence for coseismic subsidence events in a southern California coastal saltmarsh.

Paleoenvironmental records from a southern California coastal saltmarsh reveal evidence for repeated late Holocene coseismic subsidence events. Field analysis of sediment gouge cores established discrete lithostratigraphic units extend across the wetland. Detailed sediment analyses reveal abrupt changes in lithology, percent total organic matter, grain size, and magnetic susceptibility.

A modern history of psychiatric-mental health nursing.

This paper discusses the progression of developments in psychiatric-mental health nursing from the 1960s to the present. The 1960s were a time of shortage of psychiatric APRNs, with legislation expanding the availability of mental health services. We find ourselves in a similar time with 7 million new health insurance enrollees, because of the Affordable Care Act (ACA).

Identification, prevention, and treatment of children with decreased bone mineral density.

Osteoporosis in children is the presence of decreased bone mineral density in association with a significant fracture history. The amount of bone accretion in childhood and early adulthood is predictive of the risk of osteoporosis and fracture in later adulthood. A myriad of disorders and medications are associated with decreased bone mineral density in childhood.

Cold shock proteins contribute to the regulation of listeriolysin O production in Listeria monocytogenes.

Cold shock proteins (Csps) are multifunctional nucleic acid binding proteins used to regulate a wide range of gene expression responses in bacteria. We report here that Csps regulate the production of the pore-forming cytolysin listeriolysin (LLO) and hemolysis phenotypes in Listeria monocytogenes. A triple csp gene deletion mutant incapable of producing any Csps, as well as double csp gene deletion mutants only producing either CspA or CspD, caused less hemolysis and produced lower LLO concentration.

Who cares if it is a hate crime? Lesbian, gay, bisexual, and transgender hate crimes--mental health implications and interventions.

Purpose: The purpose of this paper was to discuss lesbian, gay, bisexual, or transgender-targeted hate crimes and their mental health consequences for the victim and community.

Conclusions: Hate crimes are typically more violent than nonhate-motivated crimes and have more deleterious mental health consequences.

Practice Implications: Thorough assessment coupled with an understanding of the social milieu and the meaning of the experience to the survivor can help the psychiatric nurse partner with the client to select the most appropriate treatment.

Can anesthesia trigger delayed-onset posttraumatic stress disorder in veterans?

Purpose: The clinical presentation of a 60-year-old Vietnam veteran who developed delayed-onset posttraumatic stress disorder (PTSD) after surgery is presented along with mechanisms for storing traumatic memory and a discussion of the potential contributions of anesthesia and aging to his clinical presentation.

Conclusion: Although additional research is needed to clarify the contributions of memory processes, anesthesia, and aging in delayed-onset PTSD, prudent clinicians will be cognizant of a potential correlation and screen patients appropriately.

Practice Implications: A thorough surgical and anesthetic exposure history should be explored in presentations of delayed-onset posttraumatic disorder symptomatology.

Occurrence of Vibrio spp. in fish and shellfish collected from the Swiss market.

The genus Vibrio includes gram-negative bacteria that inhabit estuarine ecosystems. V. cholerae, V.

Connectedness in community-dwelling older adults.

The purpose of this study was to examine the processes involved with connectedness in community-dwelling older adults, which the authors contend is quality of life from a generative perspective. Using a grounded theory approach, 12 older adults were interviewed using a semistructured interview guide. The tape-recorded interviews were transcribed verbatim, categories were created to code the data, and themes were extracted.

Using focus groups to understand mother-child communication about sex.

The purpose of this descriptive focus group study was to examine communication themes regarding sex and sexual risk behavior in low-income mothers of adolescent children. Focus group questions were guided by Jaccard's communication constructs. Data analysis provided three overriding themes in all five construct areas: mothers are often uncomfortable discussing sex with their male children, mothers feel strongly that their own values and beliefs must guide discussion, and mothers believe their children need developmentally appropriate information.

A comparison of two types of social support for mothers of mentally ill children.

Problem: The purpose of this analysis was to compare social support offered by two telehealth nursing interventions for mothers of children with serious mental illnesses.

Methods: A randomized, controlled, quantitative investigation is underway to test two support interventions, using the telephone (TSS) or Internet (WEB). Qualitative description was used to analyze data generated during telehealth interventions.

Development of a Web-based program to improve communication about sex.

Adolescent sexual risk behavior is a serious and prevalent problem among American youth. Mothers may play a key role in discussing sex and sexual risk behavior with their adolescent children. However, mothers may lack the knowledge and skills to successfully communicate.

Clinical course and NPHS2 analysis in patients with late steroid-resistant nephrotic syndrome.

A small fraction of patients with initial steroid-sensitive nephrotic syndrome (SSNS) develops late steroid resistance, i.e. a lack of remission after 4 weeks of relapse treatment despite previous response to steroids.

Creativity enhancement: possibilities for successful aging.

Successful aging is of growing importance in the U.S. Many researchers have explored the phenomenon using various approaches, yet we are still lacking practical guidelines on how to promote successful aging in older adults.

A fluorine scan at the catalytic center of thrombin: C--F, C--OH, and C--OMe bioisosterism and fluorine effects on pKa and log D values.

A series of 16 tricyclic thrombin inhibitors was prepared by using the 1,3-dipolar cycloaddition of azomethine ylides derived from 3- or 4-hydroxyproline and 4-bromobenzaldehyde, with N-(4-fluorobenzyl)maleimide as the key step. The terminal pyrrolidine ring of the inhibitors was systematically substituted to explore the potential bioisosteric behavior of C-F, C-OH, and C-OMe residues pointing into the environment of the catalytic center of a serine protease. X-ray crystal structure analyses revealed a distinct puckering preference of this ring.