Publications by authors named "SAIKI M"

Background: Sleep disturbances are a major public health concern in the United States, leading to adverse health outcomes. In the working population, job strain has been identified as an important risk factor for sleep disturbances, but evidence from the United States remained limited. This study aimed to examine longitudinal associations between job strain and sleep disturbances in the United States, with a focus on the alternative formulations of job strain.

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  • Immune checkpoint inhibitors combined with chemotherapy (ICI-chemo) are a standard treatment for non-small cell lung cancer (NSCLC), but the effectiveness compared to ipilimumab and nivolumab (I-N) for patients with a PD-L1 tumor proportion score (TPS) of 1-49% was not previously assessed.
  • A study involving 401 NSCLC patients analyzed treatment outcomes, finding that median overall survival (OS) was similar between the ICI-chemo group (21.0 months) and the I-N group (20.0 months), with no significant survival differences after matching for confounders.
  • However, in patients with a TPS of 25-49%, the ICI-chemo group showed a
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Introduction: Discharge planning involves coordinating between different care settings. Failed coordination can lead to delayed care at the facilities receiving discharged patients. Nurses who implement discharge planning must consider the circumstances of the staff receiving the discharged patients.

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  • Advances in cancer treatment have shifted the focus from terminal care to chronic management, requiring nurses to possess updated knowledge and teamwork skills to provide effective patient-centered care.
  • A study conducted at a Japanese university hospital analyzed the support practices of nurses involved in cancer pharmacotherapy, revealing key differences based on their years of experience.
  • Findings indicated that nurses with more experience reported significantly lower scores in providing patient-centered care, highlighting the need for improved nursing education and collaboration to better support cancer patients.
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Thoracic endovascular aortic repair (TEVAR) for thoracic aortic aneurysms (TAAs) is an alternative treatment option for high-risk patients. While conventionally performed via a transfemoral approach, it is sometimes difficult due to poor access routes. We report the case of a 90-year-old man who was incidentally diagnosed with a descending TAA while undergoing computed tomography for esophageal cancer.

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Cardiovascular disease (CVD) is becoming prevalent among younger people who have dual roles at both work and home. A possible contributor to CVD is conflict between work and home life. Thus, this study investigated the impact of work-to-family conflict (WFC) and family-to-work conflict (FWC) on metabolic risk factors.

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Selpercatinib is the first targeted therapy for rearranged during transfection (RET) fusion-positive unresectable non-small-cell lung cancer (NSCLC). The main adverse effects of selpercatinib include hypertension, liver dysfunction, diarrhea, and QT prolongation on electrocardiograms. However, instances of drug-induced interstitial lung disease (DI-ILD) are infrequently reported.

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  • A 51-year-old male experienced paresthesia in his right lower leg due to immunoglobulin G4-related disease (IgG4-RD), a rare condition that can affect the nervous system.* -
  • Initial imaging and tests suggested lymphoma and other diseases, but after further evaluation and a biopsy, it was determined to be IgG4-RD with elevated serum IgG4 levels.* -
  • Treatment with oral steroids led to improvement in symptoms and reduction in nerve root swelling, emphasizing the need for neurosurgeons to consider IgG4-RD in similar cases.*
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High pathogenicity avian influenza (HPAI) poses a significant threat to both domestic and wild birds globally. The avian influenza virus, known for environmental contamination and subsequent oral infection in birds, necessitates careful consideration of alternative introduction routes during HPAI outbreaks. This study focuses on blowflies (genus Calliphora), in particular Calliphora nigribarbis, attracted to decaying animals and feces, which migrate to lowland areas of Japan from northern or mountainous regions in early winter, coinciding with HPAI season.

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  • Primary extranodal marginal zone mucosa-associated lymphoid tissue-type B-cell lymphoma (EMZMBCL) is a rare brain tumor that can mimic more common conditions like subdural hematomas or meningiomas.
  • A 49-year-old woman with neurological symptoms underwent imaging that initially suggested an acute subdural hematoma, but further tests revealed a neoplastic lesion, leading to a diagnosis of EMZMBCL after surgery.
  • The patient received radiation therapy post-surgery, resulting in a positive outcome with no neurological deficits upon discharge, highlighting the importance of considering EMZMBCL in similar cases.
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Background: Different job strain formulations based on the Job Demand-Control model have been developed. This study evaluated longitudinal associations between job strain and psychological distress and whether associations were influenced by six formulations of job strain, including quadrant (original and simplified), subtraction, quotient, logarithm quotient, and quartile based on quotient, in randomly selected Japanese workers.

Methods: Data were from waves I and II of the Survey of Midlife in Japan (MIDJA), with a 4-year follow-up period.

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Pulmonary neuroendocrine tumors are rare, accounting for approximately 1% to 2% of lung cancers. Atypical carcinoids account for approximately 10% of pulmonary neuroendocrine tumors and are categorized as moderately malignant. Treatment options for advanced-stage atypical carcinoids include everolimus, cytotoxic anticancer agents, and peptide receptor radionuclide therapy.

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This column describes a quasi-experimental trial that examined the effects of an intervention in which both nurses and nursing assistants shared their perceptions of the nursing assistant role on the frequency of information-sharing behaviors. In the intervention group, the frequency of nurses' linguistic responses in the intervention group increased in the nursing assistants' evaluations. The frequency of nursing assistants' linguistic response and feedback in the intervention group increased in self-evaluation and nurses' evaluation, respectively.

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Objective: The objective of this review is to explore the experiences and attitudes of physicians, nurses, and nursing assistants regarding task-shifting and task-sharing in hospitals.

Introduction: Despite multiple health care professionals performing overlapping tasks, the need for effective task-shifting and task-sharing remains a concern. Understanding task-shifting and task-sharing experiences, as well as the attitudes of health care providers in hospitals, is essential for providing safe and patient-appropriate care with limited human resources.

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  • - Pituitary metastases from salivary gland cancers, like sublingual gland carcinoma, are uncommon and can be mistaken for hypophysitis due to similar imaging results, especially in patients using immune checkpoint therapies.
  • - A case study of a 52-year-old male with anorexia and visual issues revealed an intrasellar tumor that was initially suspected to be hypophysitis but was later confirmed as pituitary metastasis after ineffective corticosteroid treatment.
  • - The report underscores the importance of obtaining a pathological diagnosis in these rare cases, as imaging alone can lead to misdiagnosis and inappropriate treatment, highlighting the need for further diagnostic interventions like biopsies.
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Purpose: For patients with locally advanced non-small-cell lung cancer (LA-NSCLC) that progressed after definitive chemoradiotherapy (CRT) and durvalumab consolidation therapy, no subsequent standard treatment exists. The type of treatment selected for each timing of disease progression and its efficacy have not been investigated.

Methods: We retrospectively enrolled patients with LA-NSCLC or inoperable NSCLC that progressed after definitive CRT and durvalumab consolidation therapy at 15 Japanese institutions.

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Background: Spontaneous anterior arch fracture of the atlas after a C1 laminectomy (CIL) is an extremely rare complication.

Case Description: A 72-year-old male presented with the sudden onset of neck pain. His prior history included; a CIL for atlantoaxial subluxation, shunt closure for a spinal dural arteriovenous fistula at C3, a cervical laminoplasty from C3 to C6 for stenosis, and a prior anterior C4/5 and C5/6 fusion 14 years ago.

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Background: Among the types of lung resection procedures, pneumonectomy carries the highest risk for mortality. In recent years, bronchovascular double-sleeve lobectomy has been performed for centrally located non-small cell lung cancer involving both the bronchus and the pulmonary artery (PA) in order to avoid pneumonectomy. The use of an autologous pulmonary vein (PV) conduit for PA reconstruction during lung-sparing resections had first been reported in 2009.

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  • The study examined the effectiveness of a single-stage surgical procedure combining cervical laminoplasty and unilateral cervical foraminotomy for patients with both cervical myelopathy and unilateral radiculopathy.
  • Seven patients (average age 58.4 years) underwent this procedure, and their clinical outcomes were evaluated using various scales before and 6 months after surgery.
  • Results indicated improvements in quality of life and some pain relief in the arms and hands, suggesting that this surgical approach is both safe and potentially effective for the targeted conditions.
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Purpose: This study aimed to investigate the relationship between the expectations of unit-level nurses from nursing assistants (NAs), frequency of individual NAs' information-sharing behaviors with nurses, and the effect of NAs' self-perceived roles on this relationship. NAs provide patient care along with nurses, and their information-sharing behaviors with nurses may be influenced by the expectations of the nurses.

Methods: Nurses and NAs from 104 integrated community care (sub- and postacute) units were included in this Japanese cross-sectional study conducted from July to September 2018.

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Background: The therapeutic efficacy of cytotoxic anticancer drugs has been reported to be enhanced after immune checkpoint inhibitors (ICI) in non-small cell lung cancer; however, it is unclear whether the same is applicable for small cell lung cancer (SCLC). We evaluated the efficacy of second-line amrubicin (AMR) following first-line platinum-based chemotherapy and ICI combination therapy (chemo-ICI) in SCLC.

Patients And Methods: We retrospectively enrolled consecutive patients with SCLC treated with AMR as a second-line following chemo-ICI as first-line between July 2019 and April 2021 from 16 institutions throughout Japan.

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  • - Edo State experienced an outbreak of yellow fever from September to November 2018, prompting the Nigeria Centre for Disease Control to deploy a Rapid Response Team for investigation and management of the situation.
  • - The investigation identified 209 suspected cases, with 67 confirmed cases, a case fatality rate of 22.4%, and highlighted low vaccination coverage among the population, particularly in children.
  • - Findings indicated a significant risk of yellow fever transmission due to the presence of Aedes mosquitoes, leading to the implementation of a reactive mass vaccination campaign to control the outbreak.
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Background: Chronic inflammation due to () infection promotes gastric carcinogenesis. Tumour necrosis factor-α (TNF-α), a key mediator of inflammation, induces cell survival or apoptosis by binding to two receptors (TNFR1 and TNFR2). TNFR1 can induce both survival and apoptosis, while TNFR2 results only in cell survival.

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Since embryos change their morphology drastically in the gastrulation stage, mechanical characterization of young embryos is important as they also change their tissue stiffness with the stage of development. Herein, virtual compression tests were conducted assuming that the gastrula has a spherical shape with transverse anisotropy. Based on the design of experiments, we found that the Young's moduli and material anisotropy can be efficiently determined by measuring the reaction force and surface displacement when indenting the tester into an embryo.

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Heavy metals are natural and essential elements of the environment and living beings, produced from natural (e.g. volcanic activity and cosmic ray-induced spallation) and anthropogenic processes (e.

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