Interface Engineering of NiS@MnOH Nanorods to Efficiently Enhance Overall-Water-Splitting Activity and Stability.

Three-dimensional (3D) core-shell heterostructured NiS@MnOH nanorods grown on nickel foam (NiS@MnOH/NF) were successfully fabricated via a simple hydrothermal reaction and a subsequent electrodeposition process. The fabricated NiS@MnOH/NF shows outstanding bifunctional activity and stability for hydrogen evolution reaction and oxygen evolution reaction, as well as overall-water-splitting performance. The main origins are the interface engineering of NiS@MnOH, the shell-protection characteristic of MnOH, and the 3D open nanorod structure, which remarkably endow the electrocatalyst with high activity and stability.

Recent Advances in Antimony Sulfide-Based Nanomaterials for High-Performance Sodium-Ion Batteries: A Mini Review.

Recently, sodium-ion batteries (SIBs) have attracted extensive attention as potential alternatives to lithium-ion batteries (LIBs) due to the abundance, even distribution, low cost, and environmentally friendly nature of sodium. However, sodium ions are larger than lithium ions so that the anode materials of LIBs are not suitable for SIBs. Therefore, many negative electrode materials have been investigated.

Mcl-1 levels critically impact the sensitivities of human colorectal cancer cells to APG-1252-M1, a novel Bcl-2/Bcl-X dual inhibitor that induces Bax-dependent apoptosis.

New treatment options, such as targeted therapies, are urgently needed for the treatment of colorectal cancer (CRC), the third leading cause of cancer-related deaths worldwide. The current study focuses on demonstrating the therapeutic efficacies of APG-1252-M1 (an active form of the prodrug, APG-1252 or pelcitoclax), a highly potent Bcl-2/Bcl-X dual inhibitor in clinical trials, against CRC and understanding the underlying mechanisms. APG-1252-M1 effectively decreased the survival of CRC cell lines, particularly those expressing relatively low levels of Mcl-1, with the induction of apoptosis.

The pharmacokinetics of oral trazpiroben (TAK-906) after organic anion transporting polypeptide 1B1/1B3 inhibition: A phase I, randomized study.

Trazpiroben is a dopamine D /D receptor antagonist under development for the treatment of gastroparesis. This phase I, open-label, randomized, two-way crossover study (NCT04121078) evaluated the effect of single-dose intravenous rifampin, a potent inhibitor of the organic anion transporting polypeptides (OATPs) 1B1 and 1B3, on the pharmacokinetics and safety of trazpiroben in healthy adults. The utility of coproporphyrin (CP) I and CPIII as biomarkers of OATP inhibition was also assessed.

mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits similar B cell expansion, neutralizing responses, and protection from Omicron.

SARS-CoV-2 Omicron is highly transmissible and has substantial resistance to neutralization following immunization with ancestral spike-matched vaccines. It is unclear whether boosting with Omicron-matched vaccines would enhance protection. Here, nonhuman primates that received mRNA-1273 at weeks 0 and 4 were boosted at week 41 with mRNA-1273 or mRNA-Omicron.

Porous carbon-confined Co S nanoparticles derived from ZIF-67 for boosting lithium-ion storage.

Reasonable regulation and synthesis of hollow nanostructure materials can provide a promising electrode material for lithium-ion batteries (LIBs). In this work, utilizing a metal-organic framework (MOF, ZIF-67) as the raw material and template, a composite of Co S with a carbon shell is successfully formed through a hydrothermal vulcanization and a subsequent high temperature sintering process. The as-obtained Co S (700) material sintered at 700 °C has a large specific surface area, and at the same time possesses a hollow carbon shell structure.

Development of a Model to Predict 10-Year Risk of Ischemic and Hemorrhagic Stroke and Ischemic Heart Disease Using the China Kadoorie Biobank.

Background And Objectives: Contemporary cardiovascular disease (CVD) risk prediction models are rarely applied in routine clinical practice in China due to substantial regional differences in absolute risks of major CVD types within China. Moreover, the inclusion of blood lipids in most risk prediction models also limits their use in the Chinese population. We developed 10-year CVD risk prediction models excluding blood lipids that may be applicable to diverse regions of China.

Crystal growth engineering and origin of the weak ferromagnetism in antiferromagnetic matrix of orthochromates from - orbital hybridization.

We report a combined experimental and theoretical study on intriguing magnetic properties of quasiferroelectric orthochromates. Large single crystals of the family of RECrO (RE = Y, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, and Lu) compounds were successfully grown. Neutron Laue study indicates a good quality of the obtained single crystals.

Rewiring of 3D Chromatin Topology Orchestrates Transcriptional Reprogramming and the Development of Human Dilated Cardiomyopathy.

Background: Transcriptional reconfiguration is central to heart failure, the most common cause of which is dilated cardiomyopathy (DCM). The effect of 3-dimensional chromatin topology on transcriptional dysregulation and pathogenesis in human DCM remains elusive.

Methods: We generated a compendium of 3-dimensional epigenome and transcriptome maps from 101 biobanked human DCM and nonfailing heart tissues through highly integrative chromatin immunoprecipitation (H3K27ac [acetylation of lysine 27 on histone H3]), in situ high-throughput chromosome conformation capture, chromatin immunoprecipitation sequencing, assay for transposase-accessible chromatin using sequencing, and RNA sequencing.

Processuridia, a new genus for two new species from China and Indochina (Lepidoptera: Erebidae: Arctiinae: Lithosiini).

A new Nudariina genus, Processuridia S.-Y. Huang Volynkin gen.

Contribution to the knowledge of the genus Barsine Walker, 1854 from Xizang, China with description of a new species (Lepidoptera: Erebidae: Arctiinae: Lithosiini).

New information of the genus Barsine Walker, 1854 from Xizang Autonomous Prefecture, China is provided. A new species related to Barsine defecta Walker, 1854, B. gratissima (de Joannis, 1930), B.

Different Metabolic Phenotypes of Obesity and Risk of Coronary Artery Calcium Progression and Incident Cardiovascular Disease Events: The CARDIA Study.

Background: To investigate whether obesity with or without metabolic syndrome is prospectively associated with coronary artery calcium (CAC) progression and incident cardiovascular disease events.

Methods: A total of 1730 participants from the CARDIA study (Coronary Artery Risk Development in Young Adults) were included (age, 40.1±3.

All is not lost: learning from 9p21 loss in cancer.

The cancer research community continues to search for additional biomarkers of response and resistance to immune checkpoint treatment (ICT). The ultimate goal is to direct the use of ICT in patients whose tumors are most likely to benefit to achieve a refinement that is equivalent to that of a genotype-matched targeted treatment. Dissecting the mechanisms of ICT resistance can help us characterize ICT nonresponders more efficiently.

Mitapivat increases ATP and decreases oxidative stress and erythrocyte mitochondria retention in a SCD mouse model.

Polymerization of deoxygenated sickle hemoglobin (HbS) leads to erythrocyte sickling. Enhancing activity of the erythrocyte glycolytic pathway has anti-sickling potential as this reduces 2,3-diphosphoglycerate (2,3-DPG) and increases ATP, factors that decrease HbS polymerization and improve erythrocyte membrane integrity. These factors can be modulated by mitapivat, which activates erythrocyte pyruvate kinase (PKR) and improves sickling kinetics in SCD patients.

Tranexamic Acid in Patients Undergoing Noncardiac Surgery.

Background: Perioperative bleeding is common in patients undergoing noncardiac surgery. Tranexamic acid is an antifibrinolytic drug that may safely decrease such bleeding.

Methods: We conducted a trial involving patients undergoing noncardiac surgery.

Predicting Glaucoma Progression Requiring Surgery Using Clinical Free-Text Notes and Transfer Learning With Transformers.

Purpose: We evaluated the use of massive transformer-based language models to predict glaucoma progression requiring surgery using ophthalmology clinical notes from electronic health records (EHRs).

Methods: Ophthalmology clinical notes for 4512 glaucoma patients at a single center from 2008 to 2020 were identified from the EHRs. Four different pre-trained Bidirectional Encoder Representations from Transformers (BERT)-based models were fine-tuned on ophthalmology clinical notes from the patients' first 120 days of follow-up for the task of predicting which patients would require glaucoma surgery.

A Glycemia Risk Index (GRI) of Hypoglycemia and Hyperglycemia for Continuous Glucose Monitoring Validated by Clinician Ratings.

Background: A composite metric for the quality of glycemia from continuous glucose monitor (CGM) tracings could be useful for assisting with basic clinical interpretation of CGM data.

Methods: We assembled a data set of 14-day CGM tracings from 225 insulin-treated adults with diabetes. Using a balanced incomplete block design, 330 clinicians who were highly experienced with CGM analysis and interpretation ranked the CGM tracings from best to worst quality of glycemia.

Changes in tobacco use at the early stage of the COVID-19 pandemic: Results of four cross-sectional surveys in Hong Kong.

Introduction: Changes in tobacco use since the COVID-19 outbreak differed by countries and little is known about changes in the use of specific tobacco products.

Methods: We analyzed data from four cross-sectional telephone/online surveys from April to June 2020 to investigate such changes since the 1st and 2nd wave outbreaks (February to April 2020) in Hong Kong. The respondents were 1595 adults (83.

Integrative network analysis of early-stage lung adenocarcinoma identifies aurora kinase inhibition as interceptor of invasion and progression.

Here we focus on the molecular characterization of clinically significant histological subtypes of early-stage lung adenocarcinoma (esLUAD), which is the most common histological subtype of lung cancer. Within lung adenocarcinoma, histology is heterogeneous and associated with tumor invasion and diverse clinical outcomes. We present a gene signature distinguishing invasive and non-invasive tumors among esLUAD.

Unraveling the Conversion Evolution on Solid-State Na-SeS Battery via In Situ TEM.

All-solid-state (ASS) Na-S batteries are promising for a large-scale energy-storage system owing to numerous merits. However, the high conversion reaction barrier impedes their practical application. In this work, the basic mechanism on how Se catalyzes the conversion reaction in the Na-S batteries is unraveled.

Inverse Design of Nanoclusters for Light-Controlled CO-HCOOH Interconversion.

With global push of hydrogen economy, efficient scenarios for hydrogen storage, transportation, and generation are indispensable. Here we devise a strategy for controllable hydrogen fuel storage and retrieval via light-switched CO-to-HCOOH interconversion. To realize it, palladium sulfide nanocluster catalysts with multiple specific functionalities are directly searched by our home-developed inverse design approach based on genetic algorithm (IDOGA) and calculations.

Defect engineering of P doped FeS porous nanoparticles for high-performance asymmetric supercapacitor and oxygen evolution electrocatalyst.

Transition metal sulfides are promising battery-type materials for electrochemical energy storage and a great electrocatalyst for oxygen evolution reaction (OER). However, the poor conductivity and sluggish reaction kinetic as well as the deficiency of electrochemically active sites hinder the practical application of FeS. Herein, we design FeS porous nanoparticles with surface phosphate ions and enriched sulfur-vacancies (P-FeS), which is reported as a new high-specific-capacity material for asymmetric supercapacitor.

High-Sensitivity Troponin I after Cardiac Surgery and 30-Day Mortality.

Background: Consensus recommendations regarding the threshold levels of cardiac troponin elevations for the definition of perioperative myocardial infarction and clinically important periprocedural myocardial injury in patients undergoing cardiac surgery range widely (from >10 times to ≥70 times the upper reference limit for the assay). Limited evidence is available to support these recommendations.

Methods: We undertook an international prospective cohort study involving patients 18 years of age or older who underwent cardiac surgery.