Publications by authors named "S-S Kartha"
Chronic venous diseases, including varicose veins, are characterized by hemodynamic disturbances due to valve defects, venous insufficiency, and orthostatism. Veins are physiologically low shear stress systems, and how altered hemodynamics drives focal endothelial dysfunction and causes venous remodeling is unknown. Here we demonstrate the occurrence of endothelial to mesenchymal transition (EndMT) in human varicose veins.
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- - A new molecular framework created by linking a hydrophobic chain with tetritol using a specific chemical reaction shows promise for self-assembly applications.
- - This composite can spontaneously form organized gel structures in certain solvents, leading to the creation of nanotubes via the arrangement of the molecules.
- - The gel network can trap drugs like ibuprofen and 5-fluorouracil and offers controllable mechanical properties, with differences in how the drugs are released based on their position within the structure.
X-ray crystallographic investigations on cyclo-L-cystine show that the diketopiperazine ring is in a twisted boat form and the C-S-S-C bridge across the C alpha atoms has a negative chirality with chi 3 angle of - 94 degrees, The two peptides are significantly nonplanar with the omega values of - 10 degrees and - 16 degrees. The crystals are orthorhombic, space group P212121 with a = 11.216(4), b = 12.
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