Serum amyloid A: an ozone-induced circulating factor with potentially important functions in the lung-brain axis.

Accumulating evidence suggests that O exposure may contribute to CNS dysfunction. Here, we posit that inflammatory and acute-phase proteins in the circulation increase after O exposure and systemically convey signals of O exposure to the CNS. To model acute O exposure, female Balb/c mice were exposed to 3 ppm O or forced air for 2 h and were studied after 6 or 24 h.