Publications by authors named "S-H Kang"
Article Synopsis
- Immune checkpoint therapy (ICT) has changed the treatment landscape for malignant pleural mesothelioma (MPM), but nearly half of patients do not see benefits, emphasizing the need for predictive biomarkers.
- This study evaluated the prognostic value of serum soluble mesothelin-related peptide (SMRP) and PD-L1 levels in 125 MPM patients undergoing ICT, using statistical analyses to determine their impact on overall survival (OS).
- Results showed that higher pre-ICT SMRP levels are linked to poorer prognosis, with low levels indicating better survival outcomes, suggesting that SMRP could serve as a valuable biomarker for future MPM treatment studies.
Prognosis of Proximal and Distal Vertebrobasilar Artery Stent Placement.
AJNR Am J Neuroradiol
November 2024
Article Synopsis
- Vertebrobasilar artery stent placement (VBS) is used to prevent posterior circulation strokes, but little is known about the differences in outcomes based on whether the stent is placed intracranially or extracranially.
- In a study of 105 patients, those with intracranial VBS experienced significantly higher rates of in-stent restenosis (21.9% vs 4.9%) and stented-territory ischemic events (32.8% vs 7.3%) compared to those with extracranial VBS.
- The procedure for intracranial VBS took longer and had a higher rate of residual stenosis immediately after the procedure, indicating more complications associated with intracranial st
Article Synopsis
- Scientists used special data from a detector to look for rare particle decays of a type called the D_{s}^{+} decay, focusing on how it might change into other particles like kaons or pions.
- They found strong evidence for the decay D_{s}^{+}→π^{+}ϕ and also discovered a new decay D_{s}^{+}→ρ^{+}ϕ, both involving particles that decay into pairs of electrons.
- However, they didn't find strong signals for three other types of decays they were looking for, and set limits on how often those changes could happen.
Skin barrier dysfunction and thin epidermis are hallmarks of sensitive skin and contribute to premature aging. Avenanthramides are the primary bioactive components of colloidal oatmeal, a commonly used treatment to enhance skin barrier function. This study investigated the relationship between skin barrier function and epidermal characteristics and explored the potential of dihydroavenanthramide D (dhAvD), a synthetic avenanthramide, to improve the skin barrier.
View Article and Find Full Text PDFIntroduction: Robot-assisted radical cystectomy (RARC) has gained momentum in the management of muscle invasive bladder cancer (MIBC). Predictors of RARC outcomes are not thoroughly studied. We aim to investigate the implications of preoperative hydronephrosis on oncological outcomes.
View Article and Find Full Text PDFArticle Synopsis
- - Research on patients with normal pressure hydrocephalus (NPH) indicates that early Alzheimer's disease (AD) pathology can be detected, and this study aims to identify cerebrospinal fluid (CSF) biomarkers related to these initial AD changes.
- - The study analyzed CSF data and found that specific biomarkers such as β-amyloid-42/40 and neurofilament light chain (NfL) are correlated with AD pathology; seven key proteins were identified that also relate to both pathology and gene expression.
- - The findings suggest a link between CSF biomarkers and central nervous system changes in AD, providing valuable insights into how these markers reflect the disease's progression.
Purpose: This study aimed to assess the risk of ocular adverse events, including retinal artery occlusion (RAO), retinal vein occlusion (RVO), noninfectious uveitis (NIU), noninfectious scleritis (NIS), optic neuritis (ON), ischemic optic neuropathy (ION), and ocular motor cranial nerve palsy (OMCNP), following Coronavirus Disease 2019 (COVID-19) vaccination.
Design: Population-based self-controlled case series METHODS: This study utilized nationwide claims and vaccination data provided by the Korea National Health Insurance Service and Korea Disease Control and Prevention Agency. From the entire South Korean population of 52 million individuals, patients with incident RAO, RVO, anterior NIU, nonanterior NIU, NIS, ON, ION, or OMCNP between January 2021 and March 2022 were included.
Article Synopsis
- A study examined the safety and effectiveness of one-month dual antiplatelet therapy (DAPT) in high bleeding risk patients undergoing PCI with Resolute Onyx stents, focusing on differences between Asian and non-Asian patients.
- The results showed no significant differences in serious ischemic outcomes (like cardiac death or heart attacks) between matched groups from both regions, each with 12% incidence.
- However, Asian patients experienced significantly fewer major bleeding events (4%) compared to non-Asian patients (9%), despite similar initial bleeding risk profiles after matching.
The importance of 3D reconstruction of coronary arteries using multiple coronary angiography (CAG) images has been increasingly recognized in the field of cardiovascular disease management. This process relies on the camera matrix's optimization, needing correspondence info for identical point positions across two images. Therefore, an automatic method for determining correspondence between two CAG images is highly desirable.
View Article and Find Full Text PDFArticle Synopsis
- This study investigates genetic variants linked to outer retinal tubulation (ORT) by analyzing the prevalence and clinical consequences of ORT in patients with inherited retinal diseases (IRDs).
- A cohort of 565 IRD patients underwent SD-OCT imaging, revealing that 104 exhibited ORT, primarily associated with specific genetic variants, especially in RPE-specific and some non-RPE-specific genes.
- The findings show a strong correlation between ORT presence and IRDs caused by RPE-specific and non-RPE-specific genes, while no cases of ORT were found in patients with photoreceptor-specific gene variants.
Article Synopsis
- A series of nickel(II) dihydride complexes were synthesized, using a bis(pyrazolate) ligand, leading to various compounds including μ-sulfido and μ-hydrosulfido complexes.
- The μ-sulfido complex can be oxidized to form a bridging S-radical, characterized through various spectroscopic methods, showcasing its unique properties.
- The study highlights the importance of these complexes in understanding proton-coupled electron transfer reactions, relevant to biological systems and catalysis.
Background CT performed for various clinical indications has the potential to predict cardiometabolic diseases. However, the predictive ability of individual CT parameters remains underexplored. Purpose To evaluate the ability of automated CT-derived markers to predict diabetes and associated cardiometabolic comorbidities.
View Article and Find Full Text PDFArticle Synopsis
- * The study reveals that SPMs enhance bone formation by promoting biomineralization and activating the YAP/TAZ signaling pathway, which is crucial for osteogenic processes both in laboratory tests and in living models.
- * In experiments, SPMs were effective in increasing osteogenic gene expression and facilitating bone regeneration in mouse models, indicating their promising application in bone repair therapies.
Article Synopsis
- Cells depend on antioxidants like glutathione (GSH) for survival, with its production controlled by the enzyme GCLC.
- GSH is crucial for maintaining lipid levels in the liver, a key site for lipid production, and its deficiency affects fat storage and triglyceride levels.
- The study reveals that GSH influences lipid abundance by regulating the transcription factor NRF2, linking antioxidant function to lipid metabolism.
Article Synopsis
- A study was conducted to develop deep learning algorithms for the automatic segmentation of white matter hyperintensity (WMH) lesions in patients with cerebral infarction, involving a large dataset of 8,421 patients from multiple hospitals in Korea.
- Two models, 2D UNet and SE-Unet, were trained and validated using FLAIR MRI images, with performance measured against a human-segmented gold standard using various statistical metrics.
- Results showed that while both models had good performance, the SE-Unet outperformed the UNet with higher average Dice Similarity Coefficients (DSCs) in both internal and external validations, indicating it was more reliable for WMH segmentation.
Background: The evidence regarding perioperative adjuvant chemotherapy and personalized surveillance strategies for upper tract urothelial carcinoma is limited.
Objective: To evaluate whether adjuvant gemcitabine containing chemotherapy affects the oncological outcomes of advanced upper tract urothelial carcinoma (UTUC).
Methods: The CROES-UTUC registry is an observational, international, multi-center study on patients diagnosed with UTUC.
Adequacy of Dialysis and Incidence of Atrial Fibrillation in Patients Undergoing Hemodialysis.
Circ Cardiovasc Qual Outcomes
August 2024
Background: Atrial fibrillation (AF) can lead to stroke, heart failure, and mortality and has a greater prevalence in dialysis patients than in the general population. Several studies have suggested that uremic toxins may contribute to the development of AF. However, the association between dialysis adequacy and incident AF has not been well established.
View Article and Find Full Text PDFArticle Synopsis
- Robot-assisted radical cystectomy (RARC) is increasingly used for treating muscle invasive bladder cancer, with two main urinary diversion methods being ileal conduit and orthotopic neobladder.
- A study involving 521 patients found that those receiving neobladder had better disease-free and overall survival rates compared to those with ileal conduit, although results were not statistically significant after adjustments.
- The study concluded that neobladder is equally safe in terms of perioperative outcomes and suggests further research is needed to confirm these findings.
Article Synopsis
- The study aimed to compare the clinical outcomes of two third-generation drug-eluting stents: the Coroflex ISAR and the Orsiro.
- It was conducted as part of the HOST-IDEA trial, which originally involved dual antiplatelet therapy duration but shifted to a registry format for stent comparison, ultimately including 328 patients randomized between the two stents.
- Results showed that patients with the Coroflex ISAR stent had a significantly higher rate of target lesion failure compared to those with the Orsiro stent, with revascularization being a major factor for this difference.
Background: The Murray law-based quantitative flow ratio (μFR) is an emerging technique that requires only 1 projection of coronary angiography with similar accuracy to quantitative flow ratio (QFR). However, it has not been validated for the evaluation of noninfarct-related artery (non-IRA) in acute myocardial infarction (AMI) settings. Therefore, our study aimed to evaluate the diagnostic accuracy of μFR and the safety of deferring non-IRA lesions with μFR >0.
View Article and Find Full Text PDFBackground According to 2021 World Health Organization criteria, adult-type diffuse gliomas include glioblastoma, isocitrate dehydrogenase (IDH)-wildtype; oligodendroglioma, IDH-mutant and 1p/19q-codeleted; and astrocytoma, IDH-mutant, even when contrast enhancement is lacking. Purpose To develop and validate simple scoring systems for predicting IDH and subsequent 1p/19q codeletion status in gliomas without contrast enhancement using standard clinical MRI sequences. Materials and Methods This retrospective study included adult-type diffuse gliomas lacking contrast at contrast-enhanced MRI from two tertiary referral hospitals between January 2012 and April 2022 with diagnoses confirmed at pathology.
View Article and Find Full Text PDFArticle Synopsis
- - The EFFORT trial studied the use of ertugliflozin, a sodium-glucose cotransporter 2 inhibitor, to see if it could improve functional mitral regurgitation (MR) in heart failure patients with mildly to moderately reduced ejection fraction.
- - The trial involved 128 patients receiving either ertugliflozin or a placebo while following standard heart failure treatments, measuring their MR improvement over 12 months through various cardiac metrics.
- - Results showed that those on ertugliflozin had a significantly greater decrease in MR measurements compared to the placebo group, suggesting that ertugliflozin could effectively reduce MR and improve heart function in these patients.
To explore the effectiveness and safety of focused ultrasound ablation surgery (FUAS) for abdominal wall endometriosis. From November 2019 to October 2022, a total of 34 patients with abdominal wall endometriosis who underwent FUAS were collected, and their clinical features, imaging features, intraoperative treatment and side effects after treatment were analyzed retrospectively, and the improvement of symptoms and re-intervention were followed up. (1) Characteristics of clinical data: the average age of 34 patients with abdominal wall endometriosis was (32.
View Article and Find Full Text PDFSegments of proteins with high β-strand propensity can self-associate to form amyloid fibrils implicated in many diseases. We describe a general approach to bind such segments in β-strand and β-hairpin conformations using de novo designed scaffolds that contain deep peptide-binding clefts. The designs bind their cognate peptides in vitro with nanomolar affinities.
View Article and Find Full Text PDFBackground Blood-brain barrier (BBB) permeability change is a possible pathologic mechanism of autoimmune encephalitis. Purpose To evaluate the change in BBB permeability in patients with autoimmune encephalitis as compared with healthy controls by using dynamic contrast-enhanced (DCE) MRI and to explore its predictive value for treatment response in patients. Materials and Methods This single-center retrospective study included consecutive patients with probable or possible autoimmune encephalitis and healthy controls who underwent DCE MRI between April 2020 and May 2021.
View Article and Find Full Text PDF