Detectability of Al18F-NOTA-HER2-BCH PET for Nodal Metastases in Patients With HER2-Positive Breast Cancer.

Purpose: The aim of this study was to compare Al18F-NOTA-HER2-BCH and 18F-FDG for detecting nodal metastases in patients with HER2-positive breast cancer on PET/CT.

Patients And Methods: In this retrospective study, 62 participants with HER2-positive breast cancer underwent both Al18F-NOTA-HER2-BCH and 18F-FDG PET/CT. Participants were pathologically confirmed as HER2-positive (IHC 3+ or IHC 2+ with gene amplification on FISH).

Are "Extracurricular" Activities Really Extracurricular? The Activities That Matter Least in School Are the Ones That Best Teach Real-World Critical and Creative Thinking.

Curricula in school often do not prepare students adequately for the kinds of critical and creative thinking that they will need in their careers and lives. Part of the problem is that the characteristics of real-world problems differ greatly from the characteristics of many curricular activities, and so what the students learn in school about critical and creative thinking may fail when generalized to everyday problems. We suggest that extracurricular activities, such as in aspects of musical and athletic training, often prepare students better for real-world challenges.

A Microfluidic Biosensor for Quantitative Detection of in Traditional Chinese Medicine.

Microbial contamination is an important factor threatening the safety of Chinese medicine preparations, and microfluidic detection methods have demonstrated excellent advantages in the application of rapid bacterial detection. In our study, a novel optical biosensor was developed for the rapid and sensitive detection of in traditional Chinese medicine on a microfluidic chip. Immune gold@platinum nanocatalysts (Au@PtNCs) were utilized for specific bacterial labeling, while magnetic nano-beads (MNBs) with a novel high-gradient magnetic field were employed for the specific capture of bacteria.

Improved Entropy-Based Condition Monitoring for Pressure Pipeline Through Acoustic Denoising.

During long-term operation in complex environments, the pressure pipeline systems are prone to damage and faults, and serious safety accidents may occur without real-time condition monitoring. Moreover, in traditional non-contact monitoring approaches, acoustic signals are widely employed for condition monitoring for pressure pipelines, which are easily contaminated by background noise and provide unsatisfactory accuracy. As a tool for quantifying uncertainty and complexity, signal entropy is applied to detect abnormal conditions.

Antarctic Krill Protein Amyloid Fibrils as a Novel Iron Carrier for the Improvement of Iron Deficiency.

Iron fortification with food supplements remains the primary dietary strategy for improving iron deficiency anemia (IDA). This study used Antarctic krill protein for fibrillar design to form an Antarctic krill protein amyloid fibril (AKAF). The results indicated that peptides generated by proteolysis were a prerequisite for fibril assembly, forming elongated fibril structures and cross-linking upon heating.