Publications by authors named "S von Gierke"
IL-15 has shown preclinical activity by enhancing the functional maturation of natural killer (NK) cells. Clinical evaluation of the potential anticancer activity of most cytokines, including IL-15, has been limited by low tolerability and rapid clearance. Efbalropendekin Alfa (XmAb24306) is a soluble IL15/IL15-receptor alpha heterodimer complex fused to a half-life extended Fc domain (IL15/IL15Rα-Fc), engineered with mutations to reduce IL-15 affinity for CD122.
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- This study aimed to find out what microbes contribute to inflammatory bowel disease (IBD) by examining the bacteria present in the intestines of IBD patients.
- Researchers identified Clostridium perfringens as a toxic bacterium prevalent in the mucosal tissues of most pediatric IBD patients, even when not detected in stool samples.
- The presence of C. perfringens was linked to more severe symptoms in IBD, suggesting its toxins contribute to intestinal damage and pain in affected individuals, highlighting the need for regular monitoring in these patients.
While antisense oligonucleotides (ASOs) are used in the clinic, therapeutic development is hindered by the inability to assay ASO delivery and activity in vivo. Accordingly, we developed a dual-fluorescence, knockin mouse model that constitutively expresses mKate2 and an engineered EGFP that is alternatively spliced in the presence of ASO to induce expression. We first examined free ASO activity in the brain following intracerebroventricular injection revealing EGFP splice-switching is both ASO concentration and time dependent in major central nervous system cell types.
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- Researchers found that a gene called ATG16L1 in tumors may make colorectal cancer (a type of cancer in the colon) less responsive to a treatment called immunotherapy.
- In lab tests, removing ATG16L1 from cancer cells helped them respond better to immune system attacks, slowing down tumor growth.
- This study suggests that targeting autophagy (a process that helps cells recycle) could improve the effectiveness of immunotherapy for colorectal cancer patients.
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- Stem cells play a crucial role in maintaining rapidly renewing tissues like blood and intestines, and mutations affecting their proliferation and differentiation can lead to serious health issues.
- Researchers conducted studies by genetically targeting Rho-kinases Rock1 and Rock2 in adult mice, discovering these enzymes are essential for the health of hematopoietic (blood-forming) and gastrointestinal systems.
- Mice lacking Rho-kinases experienced cell cycle arrest in blood progenitors and impaired gut epithelial renewal, highlighting the importance of these kinases for stem cell function and overall organ integrity.