Publications by authors named "S van de Water"
Safety and immunogenicity of the live-attenuated hRVFV-4s vaccine against Rift Valley fever in healthy adults: a dose-escalation, placebo-controlled, first-in-human, phase 1 randomised clinical trial.
Lancet Infect Dis
November 2024
Background: Rift Valley fever virus, a pathogen to ruminants, camelids, and humans, is an emerging mosquito-borne bunyavirus currently endemic to Africa and the Arabian Peninsula. Although animals are primarily infected via mosquito bites, humans mainly become infected following contact with infected tissues or fluids of infected animals. There is an urgent need for adequate countermeasures, especially for humans, because effective therapeutics or vaccines are not yet available.
View Article and Find Full Text PDFBackground: High-energy transmission beams (TBs) are currently the main delivery method for proton pencil beam scanning ultrahigh dose-rate (UHDR) FLASH radiotherapy. TBs place the Bragg-peaks behind the target, outside the patient, making delivery practical and achievement of high dose-rates more likely. However, they lead to higher integral dose compared to conventional intensity-modulated proton therapy (IMPT), in which Bragg-peaks are placed within the tumor.
View Article and Find Full Text PDFThe distribution of tick-borne encephalitis virus (TBEV) is expanding to Western European countries, including the Netherlands, but the contribution of different rodent species to the transmission of TBEV is poorly understood. We investigated whether two species of wild rodents native to the Netherlands, the wood mouse Apodemus sylvaticus and the yellow-necked mouse Apodemus flavicollis, differ in their relative susceptibility to experimental infection with TBEV. Wild-caught individuals were inoculated subcutaneously with the classical European subtype of TBEV (Neudoerfl) or with TBEV-NL, a genetically divergent TBEV strain from the Netherlands.
View Article and Find Full Text PDFArticle Synopsis
- Rift Valley fever virus (RVFV) is a dangerous virus spread by mosquitoes that can make both animals and humans very sick.
- This study looked at how lambs' bodies respond to the virus using a method called RNA sequencing, which helps scientists see what’s happening at a genetic level.
- The findings showed that the virus makes it hard for the liver to work properly by reducing important enzymes, and also confirmed that certain immune responses are triggered to fight off the infection.
Article Synopsis
- - The study explores the use of FLASH radiotherapy, which delivers high dose rates (≥40 Gy/s), for whole breast irradiation (WBI), aiming to minimize damage to healthy tissue often found in the treatment area.
- - Various treatment plans were tested using ultra-high dose rate proton beams, assessing both standard five-fraction treatments and hypothetical shorter schedules of two or one fraction to enhance efficiency and effectiveness.
- - Results showed that while achieving high FLASH doses was challenging with clinically available equipment, optimizing beam configurations improved plan quality and FLASH delivery, achieving about 50% FLASH-dose in practical cases.