Publications by authors named "S van Heesch"
Article Synopsis
- Brown seaweeds are vital to coastal ecosystems, but they are threatened by climate change, prompting a detailed genetic study.
- The research traced the evolutionary history of brown algae, highlighting significant gene families and metabolic pathways related to their adaptation and functional diversity.
- Findings also indicated that the integration of large viral genomes has played a crucial role in shaping the genetics and traits of brown algal species over time.
Cancer continues to be a major global health challenge, accounting for 10 million deaths annually worldwide. Since the inception of genome-wide cancer sequencing studies 20 years ago, a core set of ~700 oncogenes and tumor suppressor genes has become the basis for cancer research. However, this research has been based largely on an understanding that the human genome encodes ~19 500 protein-coding genes.
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- Evolutionary changes in RNA translation rates and new genes, including small open reading frames, play a key role in the development of innovations in primates and rodents.
- This study examined the hearts of four primate species and two rodent species using advanced ribosome and transcriptomic profiling techniques, focusing on adult heart tissues and stem cell-derived heart cells.
- Findings revealed rapid evolution in the translation efficiency of mitochondrial complexes and identified numerous unique genomic features related to primate heart evolution, highlighting mechanisms that influence cardiac development and potential disease.
Article Synopsis
- Researchers aim to better understand the protein-coding genome due to its importance in human health, while questioning what previous genomic studies may have overlooked regarding non-canonical open reading frames (ncORFs).
- Over the last ten years, ncORFs have shown potential relevance in human cell types and diseases, but their impact on the human proteome was previously unclear, prompting a collaborative effort to analyze their protein-level evidence.
- The study found that 25% of analyzed ncORFs contribute to translated proteins, resulting in over 3,000 new peptides from extensive mass spectrometry data, and established an annotation framework and public tools to support ongoing research in this area.
Identification of immunogenic cancer neoantigens as targets for therapy is challenging. Here, we integrate the whole-genome and long-read transcript sequencing of cancers to identify the collection of neo-open reading frame peptides (NOP) expressed in tumors. We termed this collection of NOPs the tumor framome.
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