Upregulated circulating mir-424 and its' diagnostic value for gram-negative bacteremia after thoracic transplantation.

Aims: Early post-transplant complications such as acute graft rejection and infections are associated with high morbidity and mortality of heart and lung transplant recipients who are in vital need of immunosuppressive therapy. MiR-424 is a member of the miR-16 family, which plays an important physiological role in the development of cardiovascular and respiratory pathology, is involved in the regulation of monocyte and macrophage differentiation, and has an immunosuppressive potential. The aim of the study was to determine the diagnostic value of circulating miR-424 as a potential biomarker of post-transplant complications in heart and lung transplant recipients.

MiR-339 and galectin-3: diagnostic value in patients with airway obstruction after lung transplantation.

Respiratory complications can be the cause of graft dysfunction after lung transplantation (LTx). MicroRNAs are small regulatory molecules-potential biomarkers of respiratory diseases and post-transplant complications. Galectin-3 is highly expressed in fibrosis of transplanted solid organs.

[The problem of global development of antibiotic resistant nosocomial pathogens].

The problem of global expansion of multidrug-resistant nosocomial infections pathogens is under special attention at the moment. Antibiotic resistance increasing give us the limited treatment options. This problem is particularly acute for transplant clinics, because of patients need lifelong immunosuppressive therapy.

Emergence of Five Genetic Lines ST395, ST13, ST3346, ST39, and Novel ST3551 of Multidrug-Resistant Clinical in Russia.

The objective of this study was phenotypic and genotypic characterization of antibacterial-resistant clinical strains isolated in Moscow Transplantology Intensive Care Unit in 2017-2019. Major strains among ( = 63) isolated from 30 patients were recognized as extensive drug-resistant ( = 55) pathogens, and remaining strains were recognized as multidrug-resistant ( = 8) pathogens. The beta-lactamase genes ( = 63), ( = 61), ( = 54), ( = 52), and ( = 2), as well as class 1 integrons ( = 19) carried gene cassette arrays A4 ( = 2), A1C ( = 6), BA1 ( = 9), A15A1 ( = 3), and A12 ( = 1) were identified in the strains.