Synthesis, Biological Evaluation, and In Silico Modeling of -Substituted Quinoxaline-2-Carboxamides.

Despite the established treatment regimens, tuberculosis remains an alarming threat to public health according to WHO. Novel agents are needed to overcome the increasing rate of resistance and perhaps achieve eradication. As part of our long-term research on pyrazine derived compounds, we prepared a series of their ortho fused derivatives, -phenyl- and -benzyl quinoxaline-2-carboxamides, and evaluated their in vitro antimycobacterial activity.

Mortality in 504 infants weighing less than 1501 g at birth and treated in four neonatal intensive care units of south-Belgium between 1976 and 1980.

Mortality was studied in 504 infants weighing less than 1501 g at birth and treated in four neonatal intensive care units of South-Belgium between 1976 and 1980. Two hundred and twenty-one babies died during their stay at the hospital, a mortality rate of 438 per 1000 live births. The neonatal mortality rate (mortality during the first 28 days of life) was 373 per 1000 live-births.