Publications by authors named "S de Kreutzenberg"
MASLD, hepatic steatosis and fibrosis are associated with the prevalence of chronic kidney disease and retinopathy in adults with type 1 diabetes mellitus.
Diabetes Metab
January 2024
Aim: We examined whether metabolic dysfunction-associated steatotic liver disease (MASLD) with or without significant fibrosis (assessed by validated non-invasive biomarkers) was associated with an increased risk of prevalent chronic kidney disease (CKD) or diabetic retinopathy in people with type 1 diabetes mellitus (T1DM).
Methods: We performed a retrospective multicenter cross-sectional study involving 1,409 adult outpatients with T1DM, in whom hepatic steatosis index (HSI) and fibrosis (FIB)-4 index were calculated for non-invasively detecting hepatic steatosis (defined by HSI > 36), with or without coexisting significant fibrosis (FIB-4 index ≥ 1.3 or < 1.
Association between different modalities of insulin administration and metabolic dysfunction-associated fatty liver disease in adults with type 1 diabetes mellitus.
Diabetes Metab
November 2023
Article Synopsis
- - This study aimed to compare the risk of metabolic dysfunction-associated fatty liver disease (MAFLD) in adults with type 1 diabetes using either multiple daily injections (MDI) or insulin pumps (CSII).
- - Researchers analyzed data from 1,417 individuals, finding that insulin pump users tended to be younger, had better blood sugar control, and a lower prevalence of MAFLD with significant liver fibrosis compared to those on MDI.
- - The results suggested that while insulin pump therapy was linked to a lower risk of MAFLD with significant fibrosis, this association largely disappeared after adjusting for factors like age and blood sugar levels.
Hepatic steatosis with significant fibrosis is associated with an increased 10-year estimated risk of cardiovascular disease in adults with type 1 diabetes mellitus.
Cardiovasc Diabetol
August 2023
Background: We assessed whether hepatic steatosis with or without significant fibrosis (determined by validated non-invasive biomarkers) is associated with an increased 10-year estimated risk for cardiovascular disease (CVD) in people with type 1 diabetes mellitus (T1DM).
Methods: We conducted a retrospective, multicenter, cross-sectional study involving 1,254 adults with established T1DM without pre-existing CVD. We used the hepatic steatosis index (HSI) and fibrosis (FIB)-4 index for non-invasively detecting hepatic steatosis (defined as HSI > 36), with or without coexisting significant fibrosis (defined as FIB-4 index ≥ 1.
Article Synopsis
- Life history theory suggests organisms evolve to use energy efficiently to maximize fitness by balancing maintenance, growth, reproduction, and defense against threats.
- New diabetes medications, GLP-1 receptor agonists and SGLT2 inhibitors, can reduce weight and inflammation, potentially improving health outcomes beyond just lowering blood sugar.
- The use of these medications may decrease the energy cost associated with obesity and chronic inflammation, benefiting cardiovascular health as part of adult life history strategies.
Telemedicine for the Clinical Management of Diabetes; Implications and Considerations After COVID-19 Experience.
High Blood Press Cardiovasc Prev
July 2022
Telemedicine is a clinical approach that was seldom used in the day-to-day practice, if not only in certain settings, before the COVID-19 pandemic. As stated by the WHO, telemedicine is: the delivery of health care services, where distance is a critical factor, by all health care professionals using information and communication technologies (ICT) for the exchange of valid information for diagnosis, treatment and prevention of disease and injuries, …. Telemedicine has actually represented the most useful and employed tool to maintain contacts between patients and physicians during the period of physical distance imposed by the pandemic, especially during the lockdown.
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