Real-world comparison of efficacy and safety of XEN45 implant with phacoemulsification versus iStent inject® W with phacoemulsification.

Purpose: To compare iStent inject® W+phacoemulsification with XEN45 implant+phacoemulsification over 12 months in mild to moderate glaucoma patients needing cataract surgery at the Hospital General Universitario Dr. Balmis, Alicante, Spain.

Methods: Retrospective clinical cohort study.

Emerging role of IGF1R and IR expression and localisation in adrenocortical carcinomas.

Background: The insulin-like growth factor 2 (IGF2) is overexpressed in 90% of adrenocortical carcinomas (ACC) and promotes cell proliferation via IGF1R and isoform A of insulin receptor (IRA). However, IGF2 role in ACC tumourigenesis has not been completely understood yet, and the contribution of IGF1R and IRA in mediating ACC cell growth has been poorly explored. This study aimed to investigate IGF1R and IR expression and localisation, including the expression of IR isoforms, in ACC and adrenocortical adenomas (ACA), and their role in IGF2-driven proliferation.

Effect of Race/Ethnicity on In-hospital Outcomes After Radical Cystectomy.

Objective: Previously, African American race/ethnicity predisposed to higher rate of adverse in-hospital outcomes after radical cystectomy (RC). We tested whether this association applies to contemporary RC patients.

Methods: Patients were identified within the National Inpatient Sample (NIS 2000-2019).

Investigating the effect of distal screw and peg length on stability in volar plating of comminuted, intra-articular distal radius fractures in a cadaveric model.

Background: Volar plating is the preferred surgical treatment for distal radius fractures. Many have adopted unicortical distal fixation to prevent extensor tendon injury. This study aimed to determine the biomechanical effect of distal locking screws and pegs on stability in comminuted, intra-articular distal radius fracture cadavers.

In Silico Identification of Emblica officinalis Compounds Inhibiting Thermolabile Hemolysin from Vibrio alginolyticus in Shrimp.

Background: Thermolabile hemolysin (TLH) is a key virulent protein of Vibrio alginolyticus, known for its hemolytic and phospholipase activities, leading to shrimp vibriosis disease. It has been suggested as a potential therapeutic candidate for vibriosis therapy.

Methods: Computational studies, including molecular docking, toxicity analysis, and molecular dynamics (MD) simulations, were conducted to investigate the inhibition of the phospholipase activity of TLH by phytochemicals from Emblica officinalis.