Nomogram for prognosis prediction in metastatic pancreatic cancer patients undergoing intra-arterial infusion chemotherapy: incorporating immune-inflammation scores and coagulation indicators.

Background: Pancreatic cancer is one of the most malignant tumors with an inferior prognosis. This study aims to determine the prognostic significance of immune-inflammatory scores and coagulation indices in patients with metastatic pancreatic cancer(MPC) and develop a predictive nomogram.

Methods: This study retrospectively analyzed the clinical data of 384 patients with MPC who underwent intra-arterial infusion chemotherapy (IAIC).

Construction of environmentally stable self-adhesive conductive cellulose hydrogel for electronic skin sensor via autocatalytic fast polymerization strategy at room temperature.

Bio-based conductive hydrogels are catching a widespread attention in the field of flexible sensors and human-machine interface interaction. Here, an enhanced autocatalytic system constructed from dopamine-encapsulated cellulose nanofibers (DA@CNF) and Cu in a glycerol-water binary solvent achieved fast auto-polymerization of hydrogels within 60 s. X-ray photoelectron spectra (XPS), UV-vis spectrum (UV), Cyclic Voltammetry (CV) and electron paramagnetic resonance (EPR) were used to characterize the autocatalytic system.

Transcriptome analysis identifies key genes in juvenile hormone and ecdysteroid signaling pathways and their roles in regulating reproductive system development of adult Monochamus saltuarius.

Monochamus saltuarius is an important vector of pinewood nematode in Eurasia with a high reproductive capacity. Endocrine hormones play a key role in insect reproduction. Understanding the mechanism of internal regulation can provide targets for pest control.

Revealing the Anticancer Mechanism of Cephaibol A, a Peptaibol Isolated from BMC-58, Triggering Apoptosis the Mitochondrial Pathway in Human Breast Cancer Cells.

Cephaibol A was isolated from a freshwater fungus Acremonium tubakii BMC-58 extract which composed of 16 amino acids and featuring multiple α-aminoisobutyric acid. We investigated the cytotoxicity of cephaibol A on MDA-MB-231 cells to elucidate its potential antitumor activity and mechanism. The study found that cephaibol A concentration-dependently blocked the cell cycle in S phase and inhibited cell proliferation.

Prevalence of bone destruction in patients with TALAROMYCES MARNEFFEI infection: A systematic review and meta-analysis.

Objectives: This systematic review and meta-analysis aimed to evaluate the prevalence of bone destruction in patients with Talaromyces marneffei infection, examine distribution patterns of bone lesions, and assess differences between HIV-positive and HIV-negative patients.

Methods: Following PRISMA guidelines, 15 studies involving 839 patients were analyzed. Random-effects meta-analysis was performed to estimate prevalence and odds ratios.