Publications by authors named "S Zittel"
Article Synopsis
- The study investigates the effectiveness of a surgical procedure (extended strip craniectomy with bilateral barrel staving) for treating isolated craniosynostosis of the sagittal suture in infants, specifically focusing on its impact on cranial shape without directly addressing forehead issues.
- Results showed significant improvements in aspects like bossing angle and cephalic index over a year, although the cranial shape did not entirely match that of healthy peers, indicating partial normalization but not complete correction.
- The research validates 3D photogrammetry as a useful noninvasive tool for assessing cranial changes post-surgery, suggesting potential for wider clinical applications in monitoring cranial morphology.
Article Synopsis
- Dystonia is a common movement disorder with a complex genetic background, showing significant variability in its clinical presentation and genetics.
- The study involved exome sequencing of nearly 1,924 patients, mainly from two major registries, focusing on those with genetic prescreening negative results and early age at onset.
- Researchers discovered 137 likely pathogenic variants in 51 genes among the patients, with many being novel, highlighting the challenges in diagnosing and understanding the disorder's genetic links.
Age is the greatest risk factor for many neurodegenerative diseases, yet immune system aging, a contributor to neurodegeneration, is understudied. Genetic variation in the gene affects risk for both familial and sporadic Parkinson's disease (PD). The leucine-rich repeat kinase 2 (LRRK2) protein is implicated in peripheral immune cell signaling, but the effects of an aging immune system on LRRK2 function remain unclear.
View Article and Find Full Text PDFReconstruction in early squamous cell carcinoma of the oral cavity-Do free flaps improve oncological outcome?
J Stomatol Oral Maxillofac Surg
October 2024
Background: Oral squamous cell carcinoma (OSCC) ranks on position 14 in global cancer analysis and makes up to 38 % of all head and neck squamous cell carcinomas. While surgery is accepted as first-line treatment of early tumors, the reconstructive approach is not standardized. Therefore, we evaluated the concept of ablative tumor removal and microvascular reconstruction in terms of oncological safety and surgical morbidity for early OSCCs.
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