Publications by authors named "S Ziola"
Pancreatic cancer (PC) carries a poor prognosis with an overall 5-year survival of less than 10%. Early diagnosis, though cumbersome, is essential to allow complete surgical resection. Therefore, primary and secondary prevention are critical to reduce the incidence and to potentially prevent mortality.
View Article and Find Full Text PDFPurpose: to determine lactose intolerance (LI) prevalence in women with Hashimoto’s thyroiditis (HT) and assess the impact of LI on LT4 replacement dose. Methods. consecutive patients with HT underwent Lactose Breath Test and clinical/laboratory data collection.
View Article and Find Full Text PDFPharmacotherapies in eosinophilic esophagitis: state of the art.
Minerva Gastroenterol (Torino)
March 2022
Eosinophilic esophagitis is a chronic immune-mediated esophageal disease with a Th2 inflammatory response to inhalant and food allergens that cause an eosinophilic infiltration of esophageal mucosa. The diagnosis requires an upper endoscopy with esophageal bioptic samples, in particular the number of eosinophils must be >15 eos/high power field. The main symptoms of EoE in adults are dysphagia and food impaction, and its incidence is growing.
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- Therapeutic drug monitoring plays a crucial role in managing inflammatory bowel disease (IBD) patients receiving anti-TNF treatments, and this study evaluates a point-of-care (POC) method to improve clinical decision-making.
- The study involved 46 Crohn's disease patients, comparing drug trough levels using both POC and a standard homogeneous mobility shift assay (HMSA) at multiple time points to assess their effectiveness in distinguishing between remission and relapse phases.
- Results indicated that both POC and HMSA tests reliably identified remission versus relapse, with strong correlation between the two methods, suggesting that the choice of method should hinge on factors like accessibility and physician expertise rather than accuracy.
Article Synopsis
- The Lyon Consensus provides impedance-pH parameters to help diagnose gastro-oesophageal reflux disease (GERD), especially in cases where acid exposure time results are unclear.
- The study aimed to evaluate how mean nocturnal baseline impedance (MNBI) and post-reflux swallow-induced peristaltic wave (PSPW) index can aid in diagnosing GERD and predicting response to proton pump inhibitors (PPIs).
- Results showed that abnormal MNBI and PSPW index were more common in patients with inconclusive GERD diagnoses, and these abnormalities were associated with a higher likelihood of PPI response, underscoring their potential role in diagnosis and treatment decisions.