Publications by authors named "S Zia Alvi"
A simple and efficient validated assay for quantifying 21-deoxycortisol (21-DOC), 17-hydroxyprogesterone (17-OHP), cortisol, and cortisone in human plasma has been developed using ultra-high performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS). Analysis of plasma samples were performed on Atlantis dC18 (3 m) column using a mobile phase of 20.0 mM ammonium acetate and acetonitrile (50:50, : ) that was delivered at isocratic flow rate 0.
View Article and Find Full Text PDFThe naked mole-rat (NMR; ) is a eusocial subterranean rodent with a highly unusual set of physiological traits that has attracted great interest amongst the scientific community. However, the genetic basis of most of these traits has not been elucidated. To facilitate our understanding of the molecular mechanisms underlying NMR physiology and behaviour, we generated a long-read chromosomal-level genome assembly of the NMR.
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- - The study investigates how socioeconomic status (SES) and healthcare access affect the diagnosis and outcomes of childhood acute lymphoblastic leukemia (ALL) in Canada, examining data from 2001 to 2019 for children under 15 years old.
- - Researchers analyzed the connections between neighborhood income levels and distance to treatment centers in relation to high-risk features at diagnosis, treatment timeliness, and survival rates using multivariable analyses and Cox proportional hazards models.
- - Results show no significant link between income or distance from treatment centers and most outcomes; however, children in higher income brackets experienced better event-free survival, while distance to treatment was associated with greater incidence of central nervous system disease at diagnosis and differences in treatment timelines.
Article Synopsis
- This study investigates the prevalence of HIV among pregnant women in North America, focusing on data from the USA, Canada, and Mexico, as previous studies mostly centered on other global regions.
- A total of 10 relevant studies were reviewed, encompassing over 339,000 pregnant women, revealing an overall pooled HIV prevalence of 0.6%, with rates varying significantly across the three countries.
- The findings suggest that the prevalence of HIV among pregnant women in North America is considerably lower than in regions like Eastern Europe and sub-Saharan Africa, highlighting the importance of awareness and healthcare access in managing maternal health.
Pancreatic cancer (PanCa) is one of the deadliest cancers, with limited therapeutic response. Various molecular oncogenic events, including dysregulation of ribosome biogenesis, are linked to the induction, progression, and metastasis of PanCa. Thus, the discovery of new therapies suppressing these oncogenic events and ribosome biogenesis could be a novel therapeutic approach for the prevention and treatment of PanCa.
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