Publications by authors named "S Zacchigna"
Article Synopsis
- The study identifies seven microRNAs (miRNAs) that inhibit the proliferation of vascular smooth muscle cells (vSMCs), important in preventing vascular remodeling issues.
- Through high-throughput screening of 2,042 human miRNA mimics, the researchers pinpointed miR-323a-3p, miR-449b-5p, miR-491-3p, miR-892b, miR-1827, miR-4774-3p, and miR-5681b as effective in reducing vSMC proliferation.
- The findings suggest these miRNAs could be developed into therapeutic agents, particularly for conditions like vein graft failure, showing minimal toxicity and altering key cell-cycle gene networks involved in
This article is part of a themed issue Non-coding RNA Therapeutics. To view the other articles in this section visit http://onlinelibrary.wiley.
View Article and Find Full Text PDFA major obstacle in inducing therapeutic angiogenesis in the heart is inefficient gene transfer to endothelial cells (ECs). Here, we identify compounds able to enhance the permissiveness of cardiac ECs to adeno-associated virus (AAV) vectors, which stand as ideal tools for in vivo gene delivery. We screened a library of >1,500 US Food and Drug Administration (FDA)-approved drugs, in combination with AAV vectors, in cardiac ECs.
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