Publications by authors named "S ZAKARIAN"
[Effect of immune modulation on immunogenic and protective activity of a live plague vaccine].
Zh Mikrobiol Epidemiol Immunobiol
April 2015
Aim: Comparative evaluation of the effect of polyoxidonium and betaleukin on immunogenic and protective activity of a live plague vaccine in model animal experiments.
Materials And Methods: Plague vaccine EV, polyoxidonium, betaleukin, erythrocytic antigenic diagnosticum for determination of F1 antibodies and immune reagents for detection of lymphocytes with F1 receptors (LFR) in adhesive test developed by the authors were used. The experiments were carried out in 12 rabbits and 169 guinea pigs.
Article Synopsis
- Billingham and Medawar's research over thirty years ago highlighted the role of adrenocorticotrophic hormone (ACTH) and cortisol in extending the survival of skin allografts, revealing glucocorticoids' crucial role in immune regulation.
- Increased glucocorticoid secretion typically correlates with stronger immune responses, but in skin transplant rejections, levels are actually lower than normal.
- The study examines how T cell-specific factors influence the production of pituitary beta-endorphin and POMC, indicating that these hormones have an important role in transplantation immunity.
The distribution of the C-terminal glycopeptide of the vasopressin prohormone was mapped in rat brain by an immunocytochemical method using antibodies to the sheep glycopeptide. The antibodies did not react with vasopressin, oxytocin or their related neurophysins. Stained neural perikarya were observed in the hypothalamus (suprachiasmatic, paraventricular, and supraoptic nuclei) and in the bed nucleus of the stria terminalis.
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