Publications by authors named "S Z Zulkepli"
Article Synopsis
- Noise-induced hearing loss (NIHL) is a significant occupational health issue globally, with a 16% prevalence, and is particularly concerning among Malaysian Armed Forces personnel, especially marine technicians in the Royal Malaysian Navy (RMN), who are at a heightened risk due to prolonged exposure to hazardous noise levels.
- A study conducted with 127 marine technicians from RMN revealed a high prevalence of occupational NIHL at 29.9%, with various factors such as age over 30, household income, military rank, and length of service being significantly associated with the risk.
- The research utilized questionnaires and pure tone audiometric assessments to diagnose NIHL, highlighting the need for awareness and preventive measures within this occupational group.
In recent years, the number of interdisciplinary research works related to the development of miniaturized systems with integrated chemical and biological analyses is increasing. Digital microfluidic biochips (DMFBs) are one kind of miniaturized systems designed for conducting inexpensive, fast, convenient and reliable biochemical assay procedures focusing on basic scientific research and medical diagnostics. The role of a dielectric layer in the digital microfluidic biochips is prominent as it helps in actuating microliter droplets based on the electrowetting-on-dielectric (EWOD) technique.
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- A series of (E/Z)-Goniothalamin analogs were created from specific chemical compounds through a three-step process, resulting in varying levels of yield.
- Among these analogs, (Z)-Goniothalamin showed the highest cytotoxic effect against the Jurkat E6.1 T cell line, with an IC50 value of 12 μM.
- The study also found that modifications like changing the phenyl ring to other structures or altering the ring size did not enhance cytotoxicity.