[The interrelationship of the arterial and venous sections of the systemic vascular bed under the action of verapamil and propranolol].

Electromagnetic flowmetry and analogue computer techniques were used in the experiments on 12 anesthesized cats which indicated that verapamil increased cardiac output (CO) (due to lower afterload) and venous return (VR), distributed CO, by improving brain blood supply. The latter was due to more marked decrease in the vascular resistance of the brachiocephalic artery than that in the descending thoracic aorta. Propranolol diminished CO due to higher afterload, lower VR and cardiac pump function.

[Effect of nifedipine and verapamil on the interaction of arterial and venous systemic hemodynamics].

Electromagnetic flowmetry and analogue computers were used to evaluate changes in great venous and arterial blood flow and resistance alterations in the vessels after nifedipine and verapamil in experiments with 12 anesthesized cats. The agents were demonstrated to increase cardiac output due to lower afterload and venous return, to redistribute cardiac output towards greater brain blood supply. The latter was caused by a more marked decrease in vascular resistance in the brachiocephalic arterial tree than in the descending thoracic artery.

[The effect of verapamil on the course of stenocardia of effort, on the blood serum lipid level and on the basic indices of carbohydrate metabolism during the long-term use of the preparation].

The therapeutical efficiency of verapamil given for 3 months was studied in 36 patients with stable exercise-induced angina by multistep gradually increasing bicycle ergometry exercise test. The effects of the agent on serum lipid levels were evaluated in 30 cases. The therapeutical effect was achieved in 24 patients; verapamil caused a pronounced increase in physical working capacity just during the acute drug test in all cases and showing growing effects within a month of treatment.