Developing a Simple and Feasible Process for the Crude Extraction of Livetins and Phosvitin from Egg Yolk.

Due to imbalanced demand favoring egg whites, the egg industry faces a surplus of egg yolk, limiting overall growth. This study designed a feasible process for the crude extraction of livetins and phosvitin (PV) and revealed the related separation mechanisms. Our method utilized a 1:9 egg yolk dilution at pH 6.

Style mixup enhanced disentanglement learning for unsupervised domain adaptation in medical image segmentation.

Unsupervised domain adaptation (UDA) has shown impressive performance by improving the generalizability of the model to tackle the domain shift problem for cross-modality medical segmentation. However, most of the existing UDA approaches depend on high-quality image translation with diversity constraints to explicitly augment the potential data diversity, which is hard to ensure semantic consistency and capture domain-invariant representation. In this paper, free of image translation and diversity constraints, we propose a novel Style Mixup Enhanced Disentanglement Learning (SMEDL) for UDA medical image segmentation to further improve domain generalization and enhance domain-invariant learning ability.

Peripheral inflammation enhances opioid-induced gastrointestinal motility inhibition via up-regulating spinal mu opioid receptor.

Opioids are potent analgesics in clinical pain management but exert variable analgesia in different pain types. Opioid-induced constipation is a common side effect of opioid therapy, and whether opioids induce different gastrointestinal motility inhibitions in different pain types is unknown. In this study, we evaluated the antinociceptive effects and inhibition of upper gastrointestinal transit and colonic bead expulsion of morphine, DAMGO, and Deltorphin in mouse CFA chronic inflammatory pain, SNI chronic neuropathic pain, and carrageenan chronic inflammatory pain models.

Monitoring of Circulating Tumor DNA and Indication of De-Escalation Adjuvant Targeted Therapy for -Mutated NSCLC After Complete Resection.

Introduction: EGFR tyrosine kinase inhibitor (TKI) is the standard adjuvant treatment for patients with stages IB to IIIA -mutated NSCLC. Nevertheless, adapting this approach to include a molecular residual disease (MRD)-guided de-escalation strategy warrants further investigation.

Methods: From January 2019 to December 2022, 71 patients with stages I to III NSCLC and (exon 19 deletion or L858R) mutations were enrolled in this observational study.

Causal relationship between inflammatory cytokines, metabolites, and ulcers of lower limb: A Mendelian randomization study.

Inflammatory cytokines are key indicators affecting the development of ulcers of lower limb. The causal role of inflammatory cytokines in ulcers of lower limb and whether this can be mediated by metabolites remain unknown. We conducted a two-step, two-sample Mendelian randomization (MR) study to investigate the causal effect of inflammatory cytokines on ulcers of lower limb and the mediating role of metabolites in the association between inflammatory cytokines and ulcers of lower limb.