Publications by authors named "S Yoshino"
Mild glucose intolerance (positive urine glucose or mild hyperglycemia) during health checkups in young, lean women may require specialist consultation. We herein report a 31-year-old Japanese woman with mild hyperglycemia detected during a checkup who was diagnosed with overt diabetes in pregnancy and HNF4A-MODY postpartum, without prior follow-up. This case highlights the following: MODY may be present in young, lean women with mild glucose intolerance, and preconception care may improve pregnancy outcomes.
View Article and Find Full Text PDFCop1 encodes a ubiquitin E3 ligase that has been well preserved during evolution in both plants and metazoans. In metazoans, the C/EBP family transcription factors are targets for degradation by Cop1, and this process is regulated by the Tribbles pseudokinase family. Over-expression of Tribbles homolog 1 (Trib1) induces acute myeloid leukemia (AML) via Cop1-dependent degradation of the C/EBPα p42 isoform.
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- Human genetic variants influence various traits, but the underlying mechanisms are still largely unclear.
- By studying around 260,000 Japanese participants and using a specific genotype reference panel, researchers identified over 4,400 significant genetic loci linked to 63 traits, with many being novel findings.
- The study highlighted the role of noncoding variants, particularly in untranslated regions, and emphasized the importance of genetic research in diverse populations to uncover functional variants and their impacts.
Article Synopsis
- * A retrospective analysis of 230 patients showed that those with spontaneous IMA occlusion experienced lower rates of sac enlargement and higher freedom from re-intervention compared to those with a patent IMA or type II endoleak.
- * Key predictors for spontaneous IMA occlusion include lack of antiplatelet therapy, higher pre-operative hematocrit, and other specific anatomical conditions; patients with more predictors had significantly higher occlusion rates.
Highly efficient water splitting under visible light irradiation was achieved using Ir, Sb, and Al-codoped SrTiO of a single particulate metal oxide photocatalyst by a solid-state reaction followed by flux treatment using SrCl and loading of a RhCrO cocatalyst. The photocatalytic activity was improved by AlO addition to the flux treatment, and doping of small amounts of Ir and Sb. It is notable that the water splitting over the photocatalyst proceeded with response to visible light up to 660 nm.
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