Publications by authors named "S Yonezawa"
Article Synopsis
- - The study aimed to identify key transition points in neuronal development using Raman spectroscopy and dynamic network biomarker (DNB) analysis, with a focus on a post-mitotic state.
- - An in vitro model of neuronal development was previously created from rat hippocampal neurons and analyzed through principal component analysis (PCA) using Raman spectral data collected over 120 days.
- - The DNB analysis revealed that lactate (at a Raman band of 1048 cm) plays a significant role as an energy source influencing neuronal maturation, while PCA helped establish a control group for this analysis.
Purpose: Controlled ovarian stimulation (COS) is vital for IVF. We have developed an AI system to support the implementation of COS protocols in our clinical group.
Methods: We developed two models as AI algorithms of the AI system.
Integrator complex subunit 6 promotes hepatocellular steatosis via β-catenin-PPARγ axis.
Biochim Biophys Acta Mol Cell Biol Lipids
October 2024
Hepatic adipogenesis has common mechanisms with adipocyte differentiation such as PPARγ involvement and the induction of adipose tissue-specific molecules. A previous report demonstrated that integrator complex subunit 6 (INTS6) is required for adipocyte differentiation. This study aimed to investigate INTS6 expression and its role in hepatic steatosis progression.
View Article and Find Full Text PDFThe development of lipid nanoparticles (LNPs) has enabled the clinical application of small interfering ribonucleic acid (siRNA)-based therapies. Accordingly, various unique ionizable lipids have been explored for efficient siRNA delivery. However, safety concerns related to the structure of ionizable lipids have been raised.
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