Publications by authors named "S Yokoi"
Article Synopsis
- The review highlights advances in social neuroscience through the study of medaka fishes, focusing on their social cognition and mate choice behaviors, especially involving visual cues.
- Medaka fishes are advantageous for research due to their rich genetic resources and ease of genetic manipulation, making them ideal for studying evolutionary social neuroscience.
- The introduction of single-cell transcriptome technology, paired with 'Adaptive Circuitry Census,' promises to deepen understanding of molecular mechanisms behind visual mate preferences and mating strategies across species.
Background: Guillain-Barré syndrome (GBS) is a clinically heterogenous disease and encompasses several distinct clinical variants. Overlap between these variants can pose a diagnostic challenge. We report a case of finger drop variant and acute bulbar palsy overlap as an unusual manifestation of GBS.
View Article and Find Full Text PDFProtein sequence diversification significantly impacts physiological traits. In this study, using medaka fish (Oryzias latipes), we identify a novel protein variant affecting shape preference behavior. Re-analysis of sequencing data reveals that LOC101156433 encodes a unique Hmgn2 variant with unusual subnuclear localization, clustered separately from the Hmgn2 clades of other species.
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- Enfortumab vedotin (EV) is an effective treatment for patients with locally advanced or metastatic urothelial carcinoma that has progressed after immune checkpoint inhibitors, showing improved overall survival (OS) in clinical trials.
- A retrospective cohort study analyzed patients who received EV, non-EV chemotherapy, or best supportive care, concluding that the median OS was significantly higher for the EV group (20 months) compared to non-EV (15 months) and best supportive care (7 months).
- Key predictive factors for improved OS after EV treatment included age, neutrophil-to-lymphocyte ratio, dysgeusia, and rash, with NLR and dysgeusia emerging as independent predictors in multivariate analysis.
Rosai-Dorfman-Destombes disease (RDD) is a rare histiocytosis characterized by accumulation of S100 + , CD68 + , and CD1a- histiocytes, with emperipolesis. It occurs predominantly in black adolescents and young adults, but rarely in Japanese children. Recently, oncogenic mutations in mitogen-activated protein kinase (MAPK) pathway genes were reported in 30-50% of patients with RDD, and several studies have described treatment of adult patients with MAPK inhibitors.
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