Publications by authors named "S Yokohama"
Article Synopsis
- Previous studies have found both shared and population-specific genetic factors contributing to primary biliary cholangitis (PBC), with more than 20 novel susceptibility loci identified in a recent meta-analysis across different populations.
- A new genome-wide association study (GWAS) focused on the Japanese population identified the gene PTPN2 as a novel susceptibility gene for PBC, linking a specific variant (rs8098858) to the disease.
- The risk allele (rs2292758) is shown to disrupt PTPN2 expression, leading to an impaired negative feedback mechanism in immune signaling, suggesting that targeting PTPN2 could be a promising approach for PBC treatment.
Background: Chemotherapy for advanced gastric cancer is recommended in the guidelines; however, later-line treatment remains controversial. Since immune checkpoint inhibitors have been used for the treatment of various malignancies, trials have been performed for gastric cancer. A phase 3 trial indicated the survival benefit of nivolumab monotherapy for gastric cancer patients treated with prior chemotherapy regimens.
View Article and Find Full Text PDFA 26-year-old man was admitted to our hospital due to upper abdominal pain. He had previously been diagnosed with gastroduodenal ulcer at 23 and 25 years old and had been treated with proton-pump inhibitors. Endoscopic hemostasis and a biopsy were performed on the hemorrhagic gastroduodenal ulcers.
View Article and Find Full Text PDFBackground: Angiotensin II type 1 receptor blockers (ARBs) have been reported to attenuate hepatic fibrosis in non-alcoholic steatohepatitis (NASH). However, it is uncertain whether ARBs prevent hepatocarcinogenesis in NASH even after hepatic fibrosis has developed.
Methods: Male Wistar rats were fed with a choline-deficient, L-amino acid-defined (CDAA) diet for 24 weeks, and then fed with the CDAA diet with telmisartan (2 mg/kg/day), a novel ARB, or vehicle for another 24 weeks.
Possibility of oral feeding after induction of percutaneous endoscopic gastrostomy.
J Gastroenterol Hepatol
July 2010
Background And Aim: Although percutaneous endoscopic gastrostomy (PEG) has become established as a useful enteral nutrition technique, the associated risks must always be kept in mind. Recently, we experienced several patients who could orally ingest after PEG. To avoid unnecessary PEG, we investigated patients who could orally ingest after PEG, and analyzed predictive factors of postoperative oral feeding.
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