Congenital myopathy with oculo-facial abnormalities (Marden-Walker syndrome).

Marden-Walker syndrome present in the neonatal period is characterized by oculo-facial abnormalities, congenital myopathy, and contractures. A newborn infant with a similar pattern of anomalies is reported, and further evidence for autosomal recessive inheritance as well as new neuropathological findings are included.

Off-axis folded laser beam trajectories in a strip-line CO(2) laser.

Using an rf-excited strip-line CO(2) laser with large lateral dimensions (a high Fresnel number) in a hemiconfocal optical cavity configuration, we observe modes that are distinctively off axial. They can be viewed as folded Gaussian beams with trajectories in the shapes of the letters M and W. Either of these modes can be isolated by suppressing the other mode through the introduction of a suitably positioned obstacle into the cavity.

A new variant mucolipidosis: biochemical investigations on two siblings.

Biochemical studies are presented on two siblings with some features of Mucolipidosis III, but with distinctive clinical findings. Levels of beta-galatosidase, alpha-mannosidase, beta-glucuronidase, N-acetyl-beta-glucosaminidase and alpha-fucosidase found in serum from these patients ranged from 10 to 10 times higher than normal. The ratio of heat stable to heat labile serum isoenzymes of N-acetyl-beta-glucosaminidase is considerably greater than normal.