Publications by authors named "S Yasue"
Article Synopsis
- A population pharmacokinetic analysis was performed on data from 215 Japanese subjects taking oral sirolimus, identifying factors that affect the drug's pharmacokinetics across different age groups, including neonates, infants, and adults.
- The study found that sirolimus levels increased with higher hemoglobin and that the granule form had significantly higher exposure than the tablet form, while certain drugs decreased its levels significantly.
- The PopPK model developed can help customize sirolimus dosing for individuals based on their age and body weight to ensure effective treatment within the proper concentration range.
Article Synopsis
- A low-level mutation (c.182 A > G, Q61R) in the NRAS gene was found in patients with kaposiform lymphangiomatosis, but its effects on lesion environment remain unclear.
- Researchers created NRASQ61R mutated lymphatic endothelial cells to analyze their morphology, function, and protein expression.
- The NRASQ61R cells exhibited poor tube formation, low proliferation, and high migration rates, with altered signaling pathways that could be mitigated by MEK inhibitor treatment.
Introduction And Importance: The Kasabach-Merritt Phenomenon (KMP), characterized by thrombocytopenia and consumptive coagulopathy due to endothelial cell growth in the infantile vascular tumor kaposiform hemangioendothelioma, presents a therapeutic challenge. This case highlights the novel use of sirolimus in a neonate, an approach less explored in this age group.
Case Presentation: A female neonate presented with a right anterior chest mass, progressing to respiratory distress and congestive heart failure.
Article Synopsis
- Intractable lymphatic anomalies (LAs) include conditions like cystic lymphatic malformations and Gorham-Stout disease, which can cause severe symptoms, necessitating studies on potential treatments.
- A clinical trial conducted in Japan assessed the effectiveness of sirolimus, where 11 patients received daily doses and were monitored for changes in their conditions over 52 weeks.
- Results showed that 54.5% of patients experienced a partial response to treatment, with sirolimus proving to be safe and potentially improving symptoms and quality of life, although no complete responses were achieved.
Article Synopsis
- Acute acquired comitant esotropia (AACE) is a condition where individuals experience sudden double vision and eye misalignment, often linked to underlying neurological issues like brainstem tumors.
- Two pediatric patients exhibited AACE as their initial symptom, but had normal eye movements and no other neurological signs, raising suspicion of digital display overuse as a potential trigger.
- MRI was utilized to confirm the diagnosis of AACE and rule out other conditions, emphasizing the importance of imaging to differentiate between esotropia causes, particularly regarding abducens nerve involvement.