Synthesis, in vitro biological activity, hydrolytic stability and docking of new analogs of BIM-23052 containing halogenated amino acids.

One of the potent somatostatin analogs, BIM-23052 (DC-23-99) D-Phe-Phe-Phe-D-Trp-Lys-Thr-Phe-Thr-NH, has established in vitro growth hormone inhibitory activity in nM concentrations. It is also characterized by high affinity to some somatostatin receptors which are largely distributed in the cell membranes of many tumor cells. Herein, we report the synthesis of a series of analogs of BIM-23052 containing halogenated Phe residues using standard solid-phase peptide method Fmoc/OtBu-strategy.

Hematological changes in sailors from chemical cargo tankers.

Unlabelled: The group investigated consisted of 179 sailors from chemical cargo tankers, with an average age of approximately 40 years and duration of special service of between 2-6 years. They were divided into risk groups in accordance with the exposure index. The study comprised 18 voyages, transporting more than 50 chemical substances, mainly benzene, ethyl benzene, acrylonitrile, aniline, acetone, etc.