Publications by authors named "S Yamagishi"
Diabetic retinopathy (DR) is the leading cause of blindness among working-age adults, and inflammation and oxidative stress contribute to DR development. However, no effective treatments are currently approved for DR. Therefore, this study aimed to investigate the effects of SMTP-44D-a Stachybotrys microspora-derived compound with anti-inflammatory and antioxidant properties-on DR in in vivo and in vitro models.
View Article and Find Full Text PDFBackground: Basal cell carcinoma is the most common skin malignancy. The standard treatment is surgical excision with predetermined margins. Some argue that the currently recommended surgical margins are excessive, and it is questionable whether such wide surgical margins should be applied to all lesions.
View Article and Find Full Text PDFPurpose: To assess the impact of the relationship between renal pedicles and tumors on surgical outcomes in patients with non-high-risk abdominal neuroblastoma.
Methods: We retrospectively analyzed cases of neuroblastoma without metastasis treated at our hospital between March 2002 and December 2023. Cases in which surgical resection was performed were divided into three groups according to imaging findings at the time of diagnosis and before surgery: Group E (tumor encasing renal pedicles), Group C (tumor in contact with renal pedicles), and Group S (tumor separated from renal pedicles).
: Male factors contribute to approximately 50% of infertile couples. However, obvious causes remain unknown in many cases. This observational study aimed to investigate the associations of clinical and lifestyle parameters with sperm parameters.
View Article and Find Full Text PDFArticle Synopsis
- * Using mouse models, researchers found that renal injury activated the mineralocorticoid receptor (MR), which was linked to increased levels of HMGB1 and RAGE, and that blocking this pathway lessened kidney damage and inflammation.
- * Results indicate that HMGB1 is a key factor in the development of AKI and its progression to CKD by activating the Rac1/MR pathway, suggesting potential therapeutic targets for preventing kidney injury.