Objectives: This study aimed to ascertain the effect of secukinumab on erosion and enthesiophyte progression in psoriatic arthritis (PsA) by high-resolution peripheral quantitative computed tomography (HR-pQCT).
Methods: This was a phase 4, double-blind, randomized, placebo-controlled trial. Patients with active PsA and ≥ 1 erosion in the metacarpophalangeal joints (MCPJ) 2-4 were randomised in a 1:1 ratio to subcutaneous secukinumab or placebo.
Nitrate can directly activate phosphate (Pi) starvation signaling, ultimately promoting plant growth by enhancing phosphorus absorption and utilization and optimizing the balance of nitrogen and phosphorus nutrients. However, the complex mechanisms by which plants integrate complex nutrient signals from nitrogen to phosphorus are not well understood. This study highlights the importance of Calcineurin B-like protein-1 (OsCBL1), a calcium sensor, in coordinating nitrogen and phosphorus signaling in rice.
View Article and Find Full Text PDFMyeloid cells play vital roles in homeostasis and immune responses in vertebrates, but the developmental pathway underlying their lineage diversity remains elusive. Here, we construct a single-cell transcriptional map of myeloid progenitors from mouse bone marrow and conduct cross-species and developmental analyses across human, monkey, mouse, and zebrafish. We uncover a conserved specification program separating the eosinophil-basophil-mast cell (EBM) lineage and neutrophil-monocyte (NM) lineage, reclassifying myeloid cells beyond the conventional granulocytic and monocytic framework.
View Article and Find Full Text PDFThe hypergraph neural network (HGNN) is an emerging powerful tool for modeling and learning complex, high-order correlations among entities upon hypergraph structures. While existing HGNN-based approaches excel in modeling high-order correlations among data using hyperedges, they often have difficulties in distinguishing diverse semantics ( e.g.
View Article and Find Full Text PDFBackground: The larynx consists of the supraglottis, glottis, and subglottis and each differ in tissue composition, lymphatic drainage, ability to counter infections, and response to injuries. However, the cellular mechanisms driving laryngeal homoeostasis remain largely unexplored. As a result, understanding disease pathogenesis within the larynx including idiopathic subglottic stenosis (iSGS) and intubation-related traumatic stenosis has been challenging.
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