Publications by authors named "S Y Terry"
Thallium-201 is an Auger electron-emitting radionuclide with significant potential for targeted molecular radiotherapy of cancer. It stands out among other Auger electron emitters by releasing approximately 37 Auger and Coster-Kronig electrons per decay, which is one of the highest numbers in its category. It has also a convenient half-life of 73 h, a stable daughter product, established production methods, and demonstrated high radiotoxicity.
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- The research presents a new method for analyzing glycosidic linkages in polysaccharides from five types of brown seaweed, focusing on structuring their alcohol-insoluble residues (AIRs).
- This method utilizes GC-MS analysis of partially methylated alditol acetates (PMAAs) to identify variations in fucose linkages across different seaweed species, harvest years, and treatments, revealing significant structural diversity.
- It also improves cellulose quantification by addressing shortcomings in traditional methods, and introduces a pretreatment that helps detect uronic acid linkages in alginates more effectively.
Article Synopsis
- - Pseudoxanthoma elasticum (PXE) is a genetic disorder affecting skin, eyes, and blood vessels, mainly caused by mutations in the ABCC6 gene that lead to impaired calcium regulation in the body.
- - The study examined five patients from unrelated families with biallelic variants in the GGCX gene, associated with PXE-like symptoms, using next-generation sequencing for diagnosis.
- - Findings indicate that GGCX variants can also cause PXE characteristics and that patients' plasma levels of inorganic pyrophosphate (PPi) remain normal, challenging the idea that PPi levels are responsible for ectopic calcification in GGCX deficiency.
Background: Peptide receptor radionuclide therapy (PRRT) uses [Lu]Lu-[DOTA-Tyr]octreotate ([Lu]Lu-DOTA-TATE) to treat patients with neuroendocrine tumours (NETs) overexpressing the somatostatin receptor 2A (SSTR2A). It has shown significant short-term improvements in survival and symptom alleviation, but there remains room for improvement. Here, we investigated whether combining [Lu]Lu-DOTA-TATE with chemotherapeutics enhanced the in vitro therapeutic efficacy of [Lu]Lu-DOTA-TATE.
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