Regulation of autophagy and cellular signaling through non-histone protein methylation.

Autophagy is a highly conserved catabolic pathway that is precisely regulated and plays a significant role in maintaining cellular metabolic balance and intracellular homeostasis. Abnormal autophagy is directly linked to the development of various diseases, particularly immune disorders, neurodegenerative conditions, and tumors. The precise regulation of proteins is crucial for proper cellular function, and post-translational modifications (PTMs) are key epigenetic mechanisms in the regulation of numerous biological processes.

Transumbilical laparoendoscopic single-site surgery vs. multiport laparoscopic surgery for benign ovarian cysts: a retrospective cohort study.

Background: Transumbilical laparoendoscopic single-site surgery (TU-LESS) has gained increasing attention due to the potential to maximize the benefits of laparoscopic surgery. This study aimed to compare outcomes of TU-LESS and multiport laparoscopic surgery (MLS) for the treatment of benign ovarian cysts.

Methods: This retrospective cohort study included patients with benign ovarian cysts that were admitted to the Second Hospital of Hebei Medical University between September 2010 and September 2022.

Single cell transcriptomics reveals the cellular heterogeneity of keloids and the mechanism of their aggressiveness.

Keloid is a dermatofibrotic disease known for its aggressive nature and characterized by pathological scarring, which often leads to disfigurement and frequent recurrences. Effective therapies for keloids are still limited, presumably due to the inadequate comprehension of their aggressive mechanisms. In our study, we examined the unique scenario where both keloid and non-aggressive pathological scar originate from the same patient, providing a rare opportunity to explore the aggressive mechanisms of keloids through single-cell RNA sequencing.

Is more not always better? Untangling the impact of ESG disclosure transparency on idiosyncratic risk.

Environmental, social and governance (ESG) increasingly impacts firms' risk management and investment decisions. Based on instrumental stakeholder theory, this study uses data from Chinese-listed manufacturing firms from 2013 to 2021 to examine the relationship between ESG disclosure transparency and idiosyncratic risk (IR). Artificial intelligence (AI) intellectual property protection and institutional investor distraction are incorporated as moderating variables in examining this relationship.

Toxic Effects and Safety Assessment of Xanthoceras Sorbifolium Bunge Seed Kernels.

Ethnopharmacological Relevance: Xanthoceras sorbifolium Bunge (X. sorbifolia), an oil crop native to northern China, is valued for both its edible and medicinal uses. It has various applications, including the production of edible and bioactive oils, and is used in traditional medicine for its antioxidant and anti-inflammatory properties.