The rodent electronic nicotine delivery system: Apparatus for voluntary nose-only e-cigarette aerosol inhalation.

Tobacco use is the leading cause of death globally and in the United States. After decades of decline, driven by decreases in combusted tobacco use, nicotine product use has increased due to electronic nicotine delivery systems, also known as e-cigarettes or vapes. Preclinical models of nicotine self-administration can serve as important lodestars in the search for effective intervention and prevention tactics.

Identifying the best window size, lead time and sensor combination for classification of injurious versus non-injurious patient transfer from bed to wheelchair.

BackgroundPatient transfers are frequent occupational tasks of caregivers, often leading to lower back injuries. While early detection of injurious moments during patient transfers is helpful to lower the risk of such injuries, it remains a critical challenge.ObjectiveWe developed a classification model for injurious and non-injurious patient transfers using a support vector machine (SVM) with inertial measurement unit (IMU) sensor data of caregivers.

Domain-specific longitudinal associations between brain volume, white matter lesions, and cognitive function changes.

Objectives: We investigated the domain-specific patterns of the association of segmental brain volume and white matter signal abnormality (WMSA) volume with longitudinal changes in cognitive function.

Methods: Participants from an institutional health check-up program who were aged >50 years, did not have a confirmed central nervous system disorder and underwent baseline and follow-up evaluations for cognitive function and brain MRI with an interval of at least 1 year were included. Cognitive function was assessed using the Consortium to Establish a Registry for Alzheimer's Disease-Korean version (CERAD-K) assessment battery.

A randomized controlled trial comparing liquid skin adhesives and staplers for surgical wound management.

Purpose: Despite the widespread use of liquid skin adhesives (LSA), concerns persist regarding the increase in wound care costs. This study aimed to investigate the cost-effectiveness of LSA for surgical wound management.

Methods: In this prospective, open-label, single-center randomized controlled trial, adults aged 19 years and older who were scheduled for elective minimally invasive colorectal surgeries were included.

Precision repair of zone-specific meniscal injuries using a tunable extracellular matrix-based hydrogel system.

Meniscus injuries present significant therapeutic challenges due to their limited self-healing capacity and the diverse biological and mechanical properties across the tissue. Conventional repair strategies do not replicate the complex zonal characteristics within the meniscus, resulting in suboptimal outcomes. In this study, we introduce an innovative fetal/adult and stiffness-tunable meniscus decellularized extracellular matrix (DEM)-based hydrogel system designed for precision repair of heterogeneous, zonal-dependent meniscus injuries.