A Novel Oxo-Palmatine Derivative 2q as Potent Reversal Agents Against Alzheimer's Disease.

Palmatine (PAL), as an active ingredient in traditional Chinese medicine, had been demonstrated efficacy in ameliorating the manifestations of AD. Our research group has previously designed and synthesized the novel oxo-PAL derivative 2q and found that it has exhibited notable neuroprotective properties. However, compound 2q therapeutic impact on AD remains uncertain.

β-sitosterol in Yijing Hugui decoction prevents cyclophosphamide-induced premature ovarian insufficiency via the AKT1/Nrf2 pathway.

Unlabelled: Premature ovarian insufficiency (POI) is a condition marked by premature depletion of ovarian function, affecting a significant portion of women. The objective of this study is to assess the therapeutic efficacy of Yijing Hugui decoction (YJHGD) in the treatment of POI and to elucidate its pharmacological mechanisms. In this study, network pharmacology was used to identify key bioactive compounds in YJHGD, and the components were characterized using LC-MS.

Highly Efficient Color Tuning of Lithium Niobate Nanostructures on Flexible Substrate.

Nanostructures based on flexible material are essential for modulating reflected colors by actively changing the unit structure. However, current nanostructures face challenges in achieving active and efficient modulation across a broader spectral range. Here, we propose a stretchable color management method.

Strong interaction between plasmon and topological surface state in BiSe/CuS nanowires for solar-driven photothermal applications.

Developing high-performance photothermal materials and unraveling the underlying mechanism are essential for photothermal applications. Here, photothermal performance improved by strong interaction between plasmon and topological surface state (TSS) is demonstrated in BiSe/CuS nanowires. This hybrid, which CuS nanosheets were grown on BiSe nanowires, leverages the plasmon resonance and TSS-induced optical property, generating wide and efficient light absorption.

Long Noncoding RNA E2F1 Messenger RNA Stabilizing Factor (EMS) Promotes Sorafenib Resistance in Renal Cell Carcinoma by Regulating miR-363-3p and Dual-Specificity Phosphatase 10 Expression.

Renal cell carcinoma (RCC) is a common kidney disease associated with high mortality. Sorafenib is a protein kinase inhibitor that targets multiple kinases and is used for treating different cancers, including RCC. However, sorafenib resistance in patients with RCC hampers its use.