A Clinical Trial of 38% Silver Diamine Fluoride With Light Curing in Arresting Dentine Caries in Primary Teeth.

Objective: This study aimed to compare the effectiveness of semi-annual application of 38% silver diamine fluoride (SDF) with and without light curing in arresting dentine caries in primary teeth.

Methods: Children aged 5-7 years with at least 1 active dentine carious lesion were randomly allocated into: Group 1 (38% SDF with light curing: applied SDF for 10 seconds and exposed to LED light for 20 seconds) and Group 2 (38% SDF without light curing: applied SDF for 10 seconds and isolated for 20 seconds). Both interventions were repeated every 6 months.

Risk Factors for Development of Diabetes Insipidus and Syndrome of Inappropriate Antidiuretic Hormone Secretion after Transsphenoidal Resection of Pituitary Adenoma.

 We aimed to determine the incidence and risk factors for development of diabetes insipidus (DI) and syndrome of inappropriate antidiuretic hormone secretion (SIADH) after transsphenoidal hypophysectomy (TSH) for resection of a pituitary adenoma.  This was a retrospective study of 403 adult patients undergoing TSH for pituitary adenoma. Clinical variables, tumor characteristics, and operative factors were collected.

Enhancing the Transformer Model with a Convolutional Feature Extractor Block and Vector-Based Relative Position Embedding for Human Activity Recognition.

The Transformer model has received significant attention in Human Activity Recognition (HAR) due to its self-attention mechanism that captures long dependencies in time series. However, for Inertial Measurement Unit (IMU) sensor time-series signals, the Transformer model does not effectively utilize the a priori information of strong complex temporal correlations. Therefore, we proposed using multi-layer convolutional layers as a Convolutional Feature Extractor Block (CFEB).

Development of a Second-Generation, Chemical Probe for PIKfyve.

We optimized our highly potent and cell-active chemical probe for phosphatidylinositol-3-phosphate 5-kinase (PIKfyve), SGC-PIKFYVE-1, resulting in compounds with improved potency and demonstrated stability. Use of an in-cell, kinome-wide selectivity panel allowed for confirmation of excellent in-cell selectivity of our lead compound, , and another promising analogue, . Evaluation of the pharmacokinetic (PK) profiles of these two compounds revealed that both are well tolerated systemically and orally bioavailable.

An optimal protective ventilation strategy in lung resection surgery: a prospective, single-center, three-arm randomized controlled trial.

Protective ventilation reduces ventilator-induced acute lung injury postoperatively; however, the optimal strategy for one-lung ventilation (OLV) remains unclear. This study compared three protective ventilation strategies with a postoperative partial pressure of oxygen (PaO)/fraction of inspired oxygen (FiO) ratio to reduce the incidence of immediate postoperative pulmonary complications (PPCs) in patients undergoing lung resection surgery. Eighty-seven patients with ASA physical status I-III requiring OLV for lung resection surgery were randomized into three groups according to the applied ventilation strategies: low tidal volume (V) of 4 mL/kg of predicted body weight (PBW) (LV group), medium V of 6 mL/kg of PBW (MV group), and high V of 8 mL/kg of PBW (HV group).